Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?beta-Amyloid degradation and Alzheimer's diseaseAn aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrilsAlternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondriaStructure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDEAluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque depositionUbiquitin is a novel substrate for human insulin-degrading enzymeEvidence that the gene encoding insulin degrading enzyme influences human lifespanApoE promotes the proteolytic degradation of AbetaInsulin in the brain: there and back againDiverse molecular targets for therapeutic strategies in Alzheimer's diseaseDiabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stressAberrant insulin signaling in Alzheimer's disease: current knowledgeMolecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading EnzymeAnion Activation Site of Insulin-degrading EnzymeImidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysisInvolvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposureNeprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesInsulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic miceIdentification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparumHuman brain carboxypeptidase B, which cleaves beta-amyloid peptides in vitro, is expressed in the endoplasmic reticulum of neurons.Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates.Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's diseaseSynaptic and endosomal localization of active gamma-secretase in rat brain.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesProtective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation.Insulin, cognition, and dementiaAlteration of Aβ metabolism-related molecules in predementia induced by AlCl3 and D-galactoseGene expression levels as endophenotypes in genome-wide association studies of Alzheimer diseaseIDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.Microarray analysis on human neuroblastoma cells exposed to aluminum, β(1-42)-amyloid or the β(1-42)-amyloid aluminum complex.Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's preventionAn overview of APP processing enzymes and products.Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrierMultiple insulin degrading enzyme variants alter in vitro reporter gene expression
P2860
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P2860
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@ast
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@en
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@nl
type
label
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@ast
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@en
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@nl
prefLabel
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@ast
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@en
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@nl
P2860
P3181
P1433
P1476
Alzheimer's beta-amyloid pepti ...... ed by insulin degrading enzyme
@en
P2093
P2860
P3181
P356
10.1016/0014-5793(94)00387-4
P407
P577
1994-05-23T00:00:00Z