Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma

Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma

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http://www.wikidata.org/entity/Q28254999
An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma.A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing.SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IVPARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas.Association between miRNA-binding site polymorphisms in double-strand break repair genes and risk of recurrence in patients with squamous cell carcinomas of the non-oropharynx.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy.There and Back Again: The Middle Earth of DNA Repair.Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastomaTherapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation.Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor.Kinetic analyses of single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I.The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease.Repair of DNA double-strand breaks by mammalian alternative end-joining pathways.Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes.Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents
P2860

Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma

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http://www.wikidata.org/entity/Q28254999
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2015 nî lūn-bûn
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2015 թուականի Մարտին հրատարակուած գիտական յօդուած
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2015 թվականի մարտին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
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2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
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name
Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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type
label
Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
@en
Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
@en
P2093
P304
P31
P3181
P356
10.1158/1541-7786.MCR-14-0337
P407
P433
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P577
P698