Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites
about
Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptorFunctional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtypeRat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localizationA strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor.Pathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane-mediated thromboxane A2 receptor activationHuman thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysisProstanoid receptor antagonists: development strategies and therapeutic applicationsSite-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4Molecular Architecture of G Protein-Coupled Receptors.Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members.Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.Prostacyclin therapy for pulmonary arterial hypertension.Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptorPrediction of the Human EP1 Receptor Binding Site by Homology Modeling and Molecular Dynamics SimulationInvolvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis.Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist.A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor.
P2860
Q24529849-27A39954-DCAE-42F6-BA9C-A334D9E56E9CQ24530080-A504E2B5-70DD-4872-8E3C-D61F26EAAC85Q24683299-B83F0ED5-D747-41F3-A162-3345D669C527Q24813865-B3EB3E63-B54B-4189-AFF2-F93FFA3CAC39Q26864770-B6EBE5EF-8DCA-4BD5-901F-5D6E8A31499AQ28534432-325AC08B-9B6D-4D6C-B259-49563CCA1840Q33485483-D16534F7-242B-4E74-86F2-D3C046442D5EQ34137445-5E3A7FFD-CFB8-47EF-90E2-96C28BA5B0F7Q35210290-88012C82-2ADA-4EFB-8D67-99143BC37CE7Q35900876-91ED1C1A-D284-4515-A10D-51FD74302FE9Q36208460-FD27BFB0-52B2-4A77-A7E9-D41146742976Q36415271-FFAAA672-CD3D-4D08-AE9C-F5ECADC95A3FQ37789151-7BDFC521-A551-431C-9500-E22C29DCBB0CQ38298735-1127BE5F-F60B-432E-82E7-B2EEE1E697D4Q39281418-D395DC87-CB58-4691-B8B8-F01FC9A31E7BQ39957663-1484A5B7-792A-4D41-AD96-2AB6D1F30A37Q41853393-2ADBFBFF-0485-4ACD-B391-169D7FCA7D11Q42641351-79FCD1CC-5EB4-4742-B2AE-6D7EE3922B97
P2860
Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites
description
1993 nî lūn-bûn
@nan
1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Point mutation in the seventh ...... t and antagonist binding sites
@ast
Point mutation in the seventh ...... t and antagonist binding sites
@en
Point mutation in the seventh ...... t and antagonist binding sites
@nl
type
label
Point mutation in the seventh ...... t and antagonist binding sites
@ast
Point mutation in the seventh ...... t and antagonist binding sites
@en
Point mutation in the seventh ...... t and antagonist binding sites
@nl
prefLabel
Point mutation in the seventh ...... t and antagonist binding sites
@ast
Point mutation in the seventh ...... t and antagonist binding sites
@en
Point mutation in the seventh ...... t and antagonist binding sites
@nl
P2093
P1476
Point mutation in the seventh ...... t and antagonist binding sites
@en
P2093
P304
P407
P577
1993-11-01T00:00:00Z