Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation - Wikidata - wikimedia - TriplyDB

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation

http://www.wikidata.org/entity/Q28257995

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TLR2 controls intestinal carcinogen detoxication by CYP1A1 Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus.Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins In vivo biochemical and gene expression analyses of the antioxidant activities and hypocholesterolaemic properties of Tamarindus indica fruit pulp extract Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver Serum metabolomics analysis reveals impaired lipid metabolism in rats after oral exposure to benzo(a)pyrene For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes Low-dose synergistic immunosuppression of T-dependent antibody responses by polycyclic aromatic hydrocarbons and arsenic in C57BL/6J murine spleen cells Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.Inhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity.Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells.Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated mice p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA.Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants.Dioxin may promote inflammation-related development of endometriosis.The role of small-intestinal P450 enzymes in protection against systemic exposure of orally administered benzo[a]pyrene Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene.Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae)Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study.Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2.Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons.Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: implications for cancer prevention In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.

P2860

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P2860

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation

http://www.wikidata.org/entity/Q28257995

description

2004 nî lūn-bûn

@nan

2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2004年の論文

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2004年論文

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2004年論文

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2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

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2004年论文

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name

Oral exposure to benzo[a]pyren ...... tant than metabolic activation

@ast

Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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type

label

Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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prefLabel

Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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Molecular Pharmacology

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Oral exposure to benzo[a]pyren ...... tant than metabolic activation

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P2093

Christine P Curran

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Daniel W Nebert

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Howard G Shertzer

http://www.w3.org/2001/XMLSchema#string

Marian L Miller

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Sandrine Derkenne

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Shigeyuki Uno

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Timothy P Dalton

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1225-37

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scholarly article

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3621328

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10.1124/MOL.65.5.1225

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5

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65

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2004-05-01T00:00:00Z

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15102951

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