about
Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment OptionsIdiosyncratic adverse drug reactions: current conceptsDeveloping irreversible inhibitors of the protein kinase cysteinomeReversible targeting of noncatalytic cysteines with chemically tuned electrophilesIdentification of drug metabolites in human plasma or serum integrating metabolite prediction, LC-HRMS and untargeted data processing.Relationships Between Pharmacovigilance, Molecular, Structural, and Pathway Data: Revealing Mechanisms for Immune-Mediated Drug-Induced Liver Injury.Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.ADDME--Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspectiveDrug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or NecrosisLiver tissue engineering in the evaluation of drug safety.Strategies for discovering and derisking covalent, irreversible enzyme inhibitors.Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenesSynergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.Risk factors for idiosyncratic drug-induced liver injury.Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms.One size does not fit all: Challenging some dogmas and taboos in drug discovery.Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs.Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.Repeated exposure to modern volatile anaesthetics may cause chronic hepatitis as well as acute liver injuryMolecular mechanisms underlying chemical liver injury.Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.Immune mediation of hypersensitivity adverse drug reactions: implications for therapy.Idiosyncratic drug-induced agranulocytosis: the paradigm of deferiprone.Mechanisms of drug toxicity and relevance to pharmaceutical development.Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance.Drug-induced autoimmune-like hepatitis.Animal models of idiosyncratic drug-induced liver injury--current status.The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury.Idiosyncratic reactions and metabolism of sulfur-containing drugs.Idiosyncratic drug-induced liver injury: an update on the 2007 overview.An evaluation of the latest in vitro tools for drug metabolism studies.Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B.Biotransformation and bioactivation reactions of alicyclic amines in drug molecules.Targeting protein kinases with selective and semipromiscuous covalent inhibitors.Practical approaches to resolving reactive metabolite liabilities in early discovery.Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis.Human leukocyte antigen genetic risk factors of drug-induced liver toxicology.Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Idiosyncratic drug reactions: past, present, and future
@ast
Idiosyncratic drug reactions: past, present, and future
@en
Idiosyncratic drug reactions: past, present, and future
@nl
type
label
Idiosyncratic drug reactions: past, present, and future
@ast
Idiosyncratic drug reactions: past, present, and future
@en
Idiosyncratic drug reactions: past, present, and future
@nl
prefLabel
Idiosyncratic drug reactions: past, present, and future
@ast
Idiosyncratic drug reactions: past, present, and future
@en
Idiosyncratic drug reactions: past, present, and future
@nl
P3181
P356
P1476
Idiosyncratic drug reactions: past, present, and future
@en
P2093
Jack Uetrecht
P3181
P356
10.1021/TX700186P
P407
P577
2008-01-01T00:00:00Z