Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
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The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling LipidCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsIn Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.Quantitative real-time imaging of glutathioneCovalent targeting of acquired cysteines in cancerCovalent Tethering of Fragments For Covalent Probe DiscoveryStrain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity.Targeting protein kinases with selective and semipromiscuous covalent inhibitors.Targeted Covalent Inhibitors for Drug Design.Targeting biomolecules with reversible covalent chemistryLigand-Promoted C(sp(3) )-H Olefination en Route to Multi-functionalized Pyrazoles.Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible TranscriptionThiophene bridged aldehydes (TBAs) image ALDH activity in cells via modulation of intramolecular charge transfer.Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation.Enantioselective cyclopropanation of (Z)-3-substituted-2-(4-pyridyl)-acrylonitriles catalyzed by Cinchona ammonium salts.Tandem Wittig/Diels-Alder diversification of genetically encoded peptide libraries.Design, synthesis, and cytotoxic evaluation of novel scopoletin derivatives.LC-MS/MS assay for the quantitation of the tyrosine kinase inhibitor neratinib in human plasma.Catalytic asymmetric conjugate addition of isocyanoacetate to (Z)-3-substituted-2-(4-pyridyl)-acrylonitrile, a reactive class of Michael acceptor.Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues.High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.The Taxonomy of Covalent Inhibitors
P2860
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P2860
Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Design of reversible, cysteine ...... ic and computational analysis.
@ast
Design of reversible, cysteine ...... ic and computational analysis.
@en
Design of reversible, cysteine ...... ic and computational analysis.
@nl
type
label
Design of reversible, cysteine ...... ic and computational analysis.
@ast
Design of reversible, cysteine ...... ic and computational analysis.
@en
Design of reversible, cysteine ...... ic and computational analysis.
@nl
prefLabel
Design of reversible, cysteine ...... ic and computational analysis.
@ast
Design of reversible, cysteine ...... ic and computational analysis.
@en
Design of reversible, cysteine ...... ic and computational analysis.
@nl
P2093
P2860
P356
P1476
Design of reversible, cysteine ...... tic and computational analysis
@en
P2093
Boxue Tian
Jack Taunton
R Dyche Mullins
Rand M Miller
Shyam Krishnan
P2860
P304
12624-12630
P356
10.1021/JA505194W
P407
P577
2014-09-02T00:00:00Z