Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness - Wikidata - wikimedia - TriplyDB

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

http://www.wikidata.org/entity/Q28261997

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Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2 S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells Heat shock protein 90: role in enterovirus 71 entry and assembly and potential target for therapy Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 CD155/PVR plays a key role in cell motility during tumor cell invasion and migration Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure Maximizing the Therapeutic Potential of HSP90 Inhibitors Heat shock proteins at the crossroads between cancer and Alzheimer's disease Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally Chaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperones Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: implications for the prostate tumor microenvironment Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction Regulation and function of the human HSP90AA1 gene Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1 Identification of the molecular signatures integral to regenerating photoreceptors in the retina of the zebra fish Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma Antibody library-based tumor endothelial cells surface proteomic functional screen reveals migration-stimulating factor as an anti-angiogenic target Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors.Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96 Identification of cell membrane protein stress-induced phosphoprotein 1 as a potential ovarian cancer biomarker using aptamers selected by cell systematic evolution of ligands by exponential enrichment.Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes.Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits.

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Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

http://www.wikidata.org/entity/Q28261997

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2004 nî lūn-bûn

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Nature Cell Biology

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Functional proteomic screens r ...... ha in cancer cell invasiveness

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Blanca Lain

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Bradley T Scroggins

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Brenda K Eustace

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Carol Zehetmeier

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Christine Unger

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Claudia Torella

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Daniel G Jay

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Dean Yimlamai

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Gerald Beste

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Jean K Stewart

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P2860

The Hallmarks of Cancer

Hsp90: a specialized but essential protein-folding tool

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

The Promise of Integrins as Effective Targets for Anticancer Agents

Molecular portraits of human breast tumours

Genomic analysis of metastasis reveals an essential role for RhoC

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

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10.1038/NCB1131

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6

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6

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8560341

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1013482053

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15146192

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