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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

http://www.wikidata.org/entity/Q28266708

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Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells Mechanisms of Hsp90 regulation Translational progress on tumor biomarkers Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectives Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment The intracellular transport and secretion of calumenin-1/2 in living cells.Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: implications for the prostate tumor microenvironment A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme Regulation and function of the human HSP90AA1 gene Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like Protein Elastin peptides regulate HT-1080 fibrosarcoma cell migration and invasion through an Hsp90-dependent mechanism Identification of heat shock protein 90α as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis.The 4C5 cell-impermeable anti-HSP90 antibody with anti-cancer activity, is composed of a single light chain dimer Toxoplasma gondii Hsp90: potential roles in essential cellular processes of the parasite.The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.High expression of small GTPase Rab3D promotes cancer progression and metastasis Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatum Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid Hsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90α/Aha1 complex in PC3-MM2 cells.Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion.Post-translational modifications of Hsp90 and their contributions to chaperone regulation Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule.A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors.Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms.Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors.Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion.Hsp90, an unlikely ally in the war on cancer.Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles.

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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

http://www.wikidata.org/entity/Q28266708

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

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The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy

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Guodong Chang

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Hubing Shi

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Maomeng Tong

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Wei Zhuo

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Xiaofeng Wang

http://www.w3.org/2001/XMLSchema#string

Xiaomin Song

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Yan Fu

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Yongzhang Luo

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Yun Liang

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P2860

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

Active caspase-1 is a regulator of unconventional protein secretion

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

Hop modulates Hsp70/Hsp90 interactions in protein folding

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes

Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

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