about
The cell biology of HIV-1 and other retrovirusesPeptides that bind the HIV-1 integrase and modulate its enzymatic activity--kinetic studies and mode of actionA physical interaction network of dengue virus and human proteinsAntiviral restriction factor transgenesis in the domestic catVirological and cellular roles of the transcriptional coactivator LEDGF/p75Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityMouse mammary tumor virus integration site selection in human and mouse genomesLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationImpact of Chromatin on HIV ReplicationIdentification of novel nuclear targets of human thioredoxin 1Structural basis for functional tetramerization of lentiviral integrasep12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomesFunctional and structural characterization of the integrase from the prototype foamy virusA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based DesignCrystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding siteStructural basis for high-affinity binding of LEDGF PWWP to mononucleosomesNew Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of ActionDual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.A new class of multimerization selective inhibitors of HIV-1 integraseRetroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selectionIntegrating experimental and analytic approaches to improve data quality in genome-wide RNAi screensThe host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishmentLEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactorsFunctional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomesGermline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by murine leukemia virusNon-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cellsNuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domainInteraction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromerRetroviral DNA IntegrationThe emerging role of long non-coding RNAs in HIV infection.LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivityDNA double strand break repair enzymes function at multiple steps in retroviral infection.Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integrationHRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay.Integration site selection by retroviral vectors: molecular mechanism and clinical consequences.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
An essential role for LEDGF/p75 in HIV integration
@ast
An essential role for LEDGF/p75 in HIV integration
@en
An essential role for LEDGF/p75 in HIV integration
@nl
type
label
An essential role for LEDGF/p75 in HIV integration
@ast
An essential role for LEDGF/p75 in HIV integration
@en
An essential role for LEDGF/p75 in HIV integration
@nl
prefLabel
An essential role for LEDGF/p75 in HIV integration
@ast
An essential role for LEDGF/p75 in HIV integration
@en
An essential role for LEDGF/p75 in HIV integration
@nl
P2093
P3181
P356
P1433
P1476
An essential role for LEDGF/p75 in HIV integration
@en
P2093
Anne Meehan
Dyana T Saenz
Eric M Poeschla
Manuel Llano
Mary Peretz
Phonphimon Wongthida
William H Walker
P3181
P356
10.1126/SCIENCE.1132319
P407
P577
2006-10-20T00:00:00Z