A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation
about
The novel cellular mechanism of human 5-HT6 receptor through an interaction with FynMolecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formationAntidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in ratsPharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonistsCharacterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissueIn vivo effects of the 5-HT(6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartateEfficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathwaysChronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats5-HT6 receptors and Alzheimer's diseaseNeuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's diseaseIncreased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learningAVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders.Quantitative measurement of cAMP concentration using an exchange protein directly activated by a cAMP-based FRET-sensor.5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine.Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressantsE-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585.The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats.Serotonergic neuromodulation in the cerebellar cortex: cellular, synaptic, and molecular basis.Alzheimer's disease and age-related memory decline (preclinical)Identification of the adenylyl cyclase-activating 5-hydroxytryptamine receptor subtypes expressed in the rat submandibular glandCharacterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonistIdalopirdine as a treatment for Alzheimer's disease.Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.Clozapine: selective labeling of sites resembling 5HT6 serotonin receptors may reflect psychoactive profile.Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillationSerotonin and the regulation of mammalian energy balance.Assessing the neuronal serotonergic target-based antidepressant stratagem: impact of in vivo interaction studies and knockout modelsPhysical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity.5-hydroxytryptamine subtype 6 receptor modulators: a patent survey.Presynaptic control of serotonin on striatal dopamine function.Role of serotonin in Alzheimer's disease: a new therapeutic target?The serotonin-6 receptor as a novel therapeutic target.Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats.5-HT6 receptor blockade regulates primary cilia morphology in striatal neurons.Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status.Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain.
P2860
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P2860
A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation
description
1993 nî lūn-bûn
@nan
1993 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@ast
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@en
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@nl
type
label
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@ast
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@en
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@nl
prefLabel
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@ast
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@en
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@nl
P2093
P3181
P356
P1476
A novel rat serotonin (5-HT6) ...... imulation of cAMP accumulation
@en
P2093
J C Schwartz
J M Arrang
J Tardivel-Lacombe
P304
P3181
P356
10.1006/BBRC.1993.1619
P407
P577
1993-05-01T00:00:00Z