A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
about
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domainsThe diversity of calcium sensor proteins in the regulation of neuronal functionDoc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter releaseStructure activity relationship of synaptic and junctional neurotransmissionMembrane fusion: grappling with SNARE and SM proteinsRetinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent MechanismsArchitecture of the synaptotagmin-SNARE machinery for neuronal exocytosisDynamic binding mode of a Synaptotagmin-1-SNARE complex in solutionSynaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic VesiclesSynaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter releaseNeurotransmitter release: the last millisecond in the life of a synaptic vesicleDeconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypesLTP requires a unique postsynaptic SNARE fusion machineryC-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosisComplexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagminsSystematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activitiesPostsynaptic complexin controls AMPA receptor exocytosis during LTPComplexin controls the force transfer from SNARE complexes to membranes in fusionCalcium control of neurotransmitter releaseCSPα knockout causes neurodegeneration by impairing SNAP-25 functionUnderstanding synapses: past, present, and futureComplexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helixCell biology of Ca2+-triggered exocytosisStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle primingSynaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cellsImpaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant miceSynaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter releaseSNARE zipperingComplexins: small but capableMultiple roles for the actin cytoskeleton during regulated exocytosisDistinct initial SNARE configurations underlying the diversity of exocytosisThe schizophrenia risk gene product miR-137 alters presynaptic plasticity.The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavitiesMolecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusionComplexin cross-links prefusion SNAREs into a zigzag arrayPhosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentA conformational switch in complexin is required for synaptotagmin to trigger synaptic fusionComplexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activityComplexin maintains vesicles in the primed state in C. elegans
P2860
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P2860
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@ast
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@en
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@nl
type
label
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@ast
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@en
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@nl
prefLabel
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@ast
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@en
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@nl
P2093
P3181
P1433
P1476
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
@en
P2093
Anton Maximov
Jiong Tang
Ok-Ho Shin
P304
P3181
P356
10.1016/J.CELL.2006.08.030
P407
P577
2006-09-22T00:00:00Z