RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization
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Structural basis of carotenoid cleavage: from bacteria to mammalsStructure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase ActivityAnalysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)Catalytic mechanism of a retinoid isomerase essential for vertebrate visionMembrane-binding and enzymatic properties of RPE65Chemistry of the retinoid (visual) cycleAlpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activityBiochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate.The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapyAn enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brainKey enzymes of the retinoid (visual) cycle in vertebrate retinaAromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity.Identification of the key residues determining the product specificity of isomerohydrolase.Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.Utilization of Dioxygen by Carotenoid Cleavage Oxygenases.Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina.Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid MetabolismThe Biochemical Basis of Vitamin A3 Production in Arthropod VisionNew insights into retinoid metabolism and cycling within the retinaKey Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase.Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism.Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins.RPE65 gene therapy slows cone loss in Rpe65-deficient dogs.Vitamin A and Vision.RPE65 takes on another role in the vertebrate retina.
P2860
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P2860
RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization
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2010 nî lūn-bûn
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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@ast
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@en
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@nl
type
label
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@ast
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@en
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@nl
prefLabel
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@ast
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@en
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@nl
P2093
P2860
P356
P1476
RPE65, visual cycle retinol is ...... anism of retinol isomerization
@en
P2093
Eugenia Poliakov
Preethi Chander
Stephanie Kuo
Susan Gentleman
P2860
P304
P356
10.1074/JBC.M109.027458
P407
P577
2009-11-17T00:00:00Z