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Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathwayRecombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescueIdentification of RPE65 in transformed kidney cellsAge-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trialRPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerizationOrigin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebratesA History of the Classical Visual Cycle.Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter.Spectral domain optical coherence tomography in mouse models of retinal degeneration.Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturaMutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences.Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells.Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage.Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid MetabolismSubretinal delivery and electroporation in pigmented and nonpigmented adult mouse eyes.Focus on Molecules: RPE65, the visual cycle retinol isomerase.Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration.The Rpe65 rd12 allele exerts a semidominant negative effect on vision in miceFenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells.RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.In vivo gene therapy in young and adult RPE65-/- dogs produces long-term visual improvement.Expression of beta-carotene 15,15' monooxygenase in retina and RPE-choroid.Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins.Cyanogen bromide fragments of bovine interphotoreceptor retinoid-binding protein induce experimental autoimmune uveoretinitis in Lewis rats.Rat T-cell lines specific to a nonimmunodominant determinant of a retinal protein (IRBP) produce uveoretinitis and pinealitis.New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis.Immune responses to peptides derived from the retinal protein IRBP: immunopathogenic determinants are not necessarily immunodominant.Retinyl esters are the substrate for isomerohydrolase.Acute radiolabeling of retinoids in eye tissues of normal and rpe65-deficient mice.IRBP from bovine retina is poorly uveitogenic in guinea pigs and is identical to A-antigen.Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye.RPE65 takes on another role in the vertebrate retina.Synthesis of an immunopathogenic fusion protein derived from a bovine interphotoreceptor retinoid-binding protein cDNA clone.Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration.Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degenerationExpression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degenerationmRNA for interphotoreceptor retinoid-binding protein (IRBP): Distribution and size diversity in vertebrate speciesVolatile Evolution of Long Non-Coding RNA Repertoire in Retinal Pigment Epithelium: Insights from Comparison of Bovine and Human RNA Expression Profiles
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P50
description
researcher ORCID ID = 0000-0002-1813-5291
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wetenschapper
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T. Michael Redmond
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T. Michael Redmond
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T. Michael Redmond
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T. Michael Redmond
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T. Michael Redmond
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T. Michael Redmond
@en
T. Michael Redmond
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T. Michael Redmond
@nl
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T. Michael Redmond
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T. Michael Redmond
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T. Michael Redmond
@es
T. Michael Redmond
@nl
P106
P1153
35421798200
P31
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0000-0002-1813-5291