The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors
about
Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathwayTransgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signalingGIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnoverPaxillin comes of ageGIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in ratsA RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegansPhosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnoverGIT1 Paxillin-binding Domain Is a Four-helix Bundle, and It Binds to Both Paxillin LD2 and LD4 MotifsThe multifunctional GIT family of proteinsPAK signalling during the development and progression of cancerCell adhesion: integrating cytoskeletal dynamics and cellular tension.PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.Identification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis.Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.Endogenous ARF6 interacts with Rac1 upon angiotensin II stimulation to regulate membrane ruffling and cell migration.Impaired fear response in mice lacking GIT1.Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration.The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons.Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src proteinInduction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6Cell surface localization of α3β4 nicotinic acetylcholine receptors is regulated by N-cadherin homotypic binding and actomyosin contractilityGeometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter.Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells.GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillinTyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomicsGRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling.An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.Consensus nomenclature for the human ArfGAP domain-containing proteins.The PIX-GIT complex: a G protein signaling cassette in control of cell shapeAnxiety-like behaviors in mice lacking GIT2.How important are Rho GTPases in neurosecretion?Untangling the complexity of PAK1 dynamics: The future challenge.
P2860
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P2860
The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@ast
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@en
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@nl
type
label
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@ast
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@en
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@nl
prefLabel
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@ast
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@en
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@nl
P2093
P3181
P1433
P1476
The GIT/PIX complex: an oligom ...... ne nucleotide exchange factors
@en
P2093
Audrey Claing
J Tyler Roseman
Richard T Premont
Robert Schmalzigaug
Stephen J Perry
Yanghui Xing
P304
P3181
P356
10.1016/J.CELLSIG.2004.02.002
P407
P577
2004-09-01T00:00:00Z