A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease
about
A novel mutation in the HSD17B10 gene of a 10-year-old boy with refractory epilepsy, choreoathetosis and learning disabilityComparative evolutionary genomics of the HADH2 gene encoding Abeta-binding alcohol dehydrogenase/17beta-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10)Intrinsic alcohol dehydrogenase and hydroxysteroid dehydrogenase activities of human mitochondrial short-chain L-3-hydroxyacyl-CoA dehydrogenase2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene.Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolismPurification, crystallization and preliminary crystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase fromCaenorhabditis elegansBinding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's diseaseHuman brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenaseCharacterization and localization of human type10 17beta-hydroxysteroid dehydrogenaseHyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretionAmyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).Cellular cofactors for amyloid beta-peptide-induced cell stress. Moving from cell culture to in vivo.X-inactivation of HSD17B10 revealed by cDNA analysis in two female patients with 17β-hydroxysteroid dehydrogenase 10 deficiency.The amyloid-β-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P.Transcription start sites and epigenetic analysis of the HSD17B10 proximal promoterDimerization interface of 3-hydroxyacyl-CoA dehydrogenase tunes the formation of its catalytic intermediate.Determination of small molecule ABAD inhibitors crossing blood-brain barrier and pharmacokineticsGene network effects on brain microstructure and intellectual performance identified in 472 twinsA novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regressionThe consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.HSD10 disease: clinical consequences of mutations in the HSD17B10 gene.Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex.beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria.Clinical and molecular analysis of 6 Chinese patients with isoleucine metabolism defects: identification of 3 novel mutations in the HSD17B10 and ACAT1 gene.Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity.Re: Hadh2 and 3-hydroxyacyl-CoA dehydrogenase.
P2860
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P2860
A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@ast
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@en
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@nl
type
label
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@ast
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@en
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@nl
prefLabel
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@ast
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@en
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@nl
P2093
P2860
P356
P1476
A human brain L-3-hydroxyacyl- ...... nvolved in Alzheimer's disease
@en
P2093
P2860
P304
P356
10.1074/JBC.273.17.10741
P407
P577
1998-04-24T00:00:00Z