about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Mammalian target of rapamycin: a central node of complex signaling cascadesMicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cellsPotential use of rapamycin in HIV infectionThe mTOR signalling pathway in human cancerRapamycin and mTOR kinase inhibitorsRapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instabilityThe cilia-regulated proteasome and its role in the development of ciliopathies and cancerRole of Redox Status in Development of GlioblastomaNew Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of AutophagyReciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy.PI3K/PTEN signaling in angiogenesis and tumorigenesisA systematic analysis of a mi-RNA inter-pathway regulatory motifS6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage responseThe synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrenceIntegration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.Outcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide.Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions.The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agentImmunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolismTargeting the translational machinery as a novel treatment strategy for hematologic malignanciesTargeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagyInhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachFisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations.mTOR signaling in glioblastoma: lessons learned from bench to bedside.Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression.Basal autophagy induction without AMP-activated protein kinase under low glucose conditions.PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathwayLongitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways.Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.Efficacy and comparative effectiveness of sirolimus as an anticancer drug.AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradationThe effect of leucine restriction on Akt/mTOR signaling in breast cancer cell lines in vitro and in vivo.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
mTOR and cancer therapy
@ast
mTOR and cancer therapy
@en
mTOR and cancer therapy
@nl
type
label
mTOR and cancer therapy
@ast
mTOR and cancer therapy
@en
mTOR and cancer therapy
@nl
prefLabel
mTOR and cancer therapy
@ast
mTOR and cancer therapy
@en
mTOR and cancer therapy
@nl
P2860
P3181
P356
P1433
P1476
mTOR and cancer therapy
@en
P2093
J B Easton
P J Houghton
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1209886
P407
P577
2006-10-16T00:00:00Z
P5875
P6179
1001751169