Targeting the translational machinery as a novel treatment strategy for hematologic malignancies
about
Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignanciesStructure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4GA genome-wide systematic analysis reveals different and predictive proliferation expression signatures of cancerous vs. non-cancerous cellsResistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTORTranslation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonizationOmacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemiaDetection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma.Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.eIF3 controls cell size independently of S6K1-activity.Regulation of the kinase RSK1 by arsenic trioxide and generation of antileukemic responsesTargeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell functionFunctional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLCDown-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines.Regulation and deregulation of mRNA translation during myeloid maturation.Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance.Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells.Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells.Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.Coexpression Pattern Analysis of NPM1-Associated Genes in Chronic Myelogenous Leukemia.Enhancing proteotoxic stress as an anticancer strategy.Targeting EIF4F complex in non-small cell lung cancer cells.AMPK signaling: a targetable tumor suppressor pathway?Eukaryotic Translation Initiation Factor 3b is both a Promising Prognostic Biomarker and a Potential Therapeutic Target for Patients with Clear Cell Renal Cell Carcinoma.IMiD immunomodulatory compounds block C/EBP{beta} translation through eIF4E down-regulation resulting in inhibition of MM.MicroRNA-379 inhibits the proliferation, migration and invasion of human osteosarcoma cells by targetting EIF4G2PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis.Gene expression-based risk score in diffuse large B-cell lymphoma.Serum starvation: caveat emptor.Eukaryotic Elongation Factor 2 (eEF2) is a Potential Biomarker of Prostate Cancer.Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia.Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL.Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells.CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM
P2860
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P2860
Targeting the translational machinery as a novel treatment strategy for hematologic malignancies
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeting the translational ma ...... y for hematologic malignancies
@ast
Targeting the translational ma ...... y for hematologic malignancies
@en
type
label
Targeting the translational ma ...... y for hematologic malignancies
@ast
Targeting the translational ma ...... y for hematologic malignancies
@en
prefLabel
Targeting the translational ma ...... y for hematologic malignancies
@ast
Targeting the translational ma ...... y for hematologic malignancies
@en
P2093
P2860
P1433
P1476
Targeting the translational ma ...... y for hematologic malignancies
@en
P2093
Abraham Schneider
Patrick R Hagner
Ronald B Gartenhaus
P2860
P304
P356
10.1182/BLOOD-2009-09-220020
P407
P577
2010-01-14T00:00:00Z