Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia
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Sugar consumption, metabolic disease and obesity: The state of the controversyMissense mutation in APOC3 within the C-terminal lipid binding domain of human ApoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: evidence that ApoC-III plays a major role in the formation of lLoss-of-function mutations in APOC3, triglycerides, and coronary diseaseRecent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion.Complexities of plasma apolipoprotein C-III metabolismGenetic determinants of plasma triglyceridesLow triglyceride levels are associated with a better metabolic control in patients with type 1 diabetes.Associations of the APOC3 rs5128 polymorphism with plasma APOC3 and lipid levels: a meta-analysisHepatic ABCA1 and VLDL triglyceride production.Apolipoprotein C-III: a potent modulator of hypertriglyceridemia and cardiovascular disease.Lipoprotein metabolism in nonalcoholic fatty liver diseaseChanges in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces.Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects.Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets.Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymphThe regulation of ApoB metabolism by insulin.Intracellular role of exchangeable apolipoproteins in energy homeostasis, obesity and non-alcoholic fatty liver disease.A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.Targeting ApoC-III to Reduce Coronary Disease Risk.Secretion of triacylglycerol-poor VLDL particles from McA-RH7777 cells expressing human hepatic lipase.Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition.A Novel Role for RARα Agonists as Apolipoprotein CIII Inhibitors Identified from High Throughput Screening.Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families.Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII.Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an APOC3 Founder Mutation.The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr-/- mice with diet-induced insulin resistance.APOC3 Protein Is Not a Predisposing Factor for Fat-induced Nonalcoholic Fatty Liver Disease in Mice.Partner in fat metabolism: role of KLFs in fat burning and reproductive behavior.
P2860
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P2860
Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Functional analysis of the mis ...... with human hypotriglyceridemia
@ast
Functional analysis of the mis ...... with human hypotriglyceridemia
@en
Functional analysis of the mis ...... with human hypotriglyceridemia
@nl
type
label
Functional analysis of the mis ...... with human hypotriglyceridemia
@ast
Functional analysis of the mis ...... with human hypotriglyceridemia
@en
Functional analysis of the mis ...... with human hypotriglyceridemia
@nl
prefLabel
Functional analysis of the mis ...... with human hypotriglyceridemia
@ast
Functional analysis of the mis ...... with human hypotriglyceridemia
@en
Functional analysis of the mis ...... with human hypotriglyceridemia
@nl
P2093
P2860
P3181
P356
P1476
Functional analysis of the mis ...... with human hypotriglyceridemia
@en
P2093
Daniel Figeys
Jahangir Iqbal
M Mahmood Hussain
Maroun Bou Khalil
Meenakshi Sundaram
Shumei Zhong
Yuwei Wang
P2860
P304
P3181
P356
10.1194/JLR.M005108
P407
P577
2010-06-01T00:00:00Z