Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53
about
The transcription factor p53: not a repressor, solely an activatorMutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type IIG-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53.Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.p53 induces distinct epigenetic states at its direct target promoters.Mutant p53 gain-of-function in cancer.Contribution of p53 to metastasis.SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of functionMet-related receptor tyrosine kinase Ron in tumor growth and metastasis.Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistanceMutant p53 cooperates with ETS2 to promote etoposide resistance.The Expression and Correlation of iNOS and p53 in Oral Squamous Cell CarcinomaStructural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells.Combined analysis of DNA methylome and transcriptome reveal novel candidate genes with susceptibility to bovine Staphylococcus aureus subclinical mastitis.Differential regulation of the REGγ-proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells.p53 and its mutants in tumor cell migration and invasion.Mutant p53 in cancer: new functions and therapeutic opportunities.Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells.p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity.Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter.
P2860
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P2860
Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@ast
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@en
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@nl
type
label
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@ast
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@en
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@nl
prefLabel
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@ast
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@en
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@nl
P2093
P3181
P356
P1433
P1476
Repression of the MSP/MST-1 ge ...... gain of function of mutant p53
@en
P2093
P2888
P304
P3181
P356
10.1038/SJ.ONC.1209061
P407
P50
P577
2006-01-01T00:00:00Z
P5875
P6179
1052964204