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Colorectal cancer and genetic alterations in the Wnt pathway

Colorectal cancer and genetic alterations in the Wnt pathway

http://www.wikidata.org/entity/Q28276998

about

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor A transposon-based genetic screen in mice identifies genes altered in colorectal cancer Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway Targeting cancer stem cells by using the nanoparticles Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction The double life of KLF5: Opposing roles in regulation of gene-expression, cellular function, and transformation Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis TLR4 activates the β-catenin pathway to cause intestinal neoplasia Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301 Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis Age-specific incidence of cancer: Phases, transitions, and biological implications Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease.Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling MeInfoText: associated gene methylation and cancer information from text mining.TCF/beta-catenin plays an important role in HCCR-1 oncogene expression Impact of human pathogenic micro-insertions and micro-deletions on post-transcriptional regulation.Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer.Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling.Nuclear β-Catenin Expression is Frequent in Sinonasal Hemangiopericytoma and Its Mimics.Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model.The Epigenomics of Embryonic Pathway Signaling in Colorectal Cancer.Integrin α6A splice variant regulates proliferation and the Wnt/β-catenin pathway in human colorectal cancer cells.Regulation and regulatory role of WNT signaling in potentiating FSH action during bovine dominant follicle selection.Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis.Cancer inflammation and regulatory T cells.An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer.

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P2860

Colorectal cancer and genetic alterations in the Wnt pathway

http://www.wikidata.org/entity/Q28276998

description

2006 nî lūn-bûn

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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Colorectal cancer and genetic alterations in the Wnt pathway

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Colorectal cancer and genetic alterations in the Wnt pathway

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Colorectal cancer and genetic alterations in the Wnt pathway

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type

label

Colorectal cancer and genetic alterations in the Wnt pathway

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Colorectal cancer and genetic alterations in the Wnt pathway

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Colorectal cancer and genetic alterations in the Wnt pathway

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prefLabel

Colorectal cancer and genetic alterations in the Wnt pathway

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Colorectal cancer and genetic alterations in the Wnt pathway

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Colorectal cancer and genetic alterations in the Wnt pathway

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Colorectal cancer and genetic alterations in the Wnt pathway

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I Tomlinson

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S Segditsas

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P2860

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

The Wnt antagonist sFRP1 in colorectal tumorigenesis

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.

Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.

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colorectal cancer