An SCN9A channelopathy causes congenital inability to experience pain - Wikidata - wikimedia - TriplyDB

An SCN9A channelopathy causes congenital inability to experience pain

An SCN9A channelopathy causes congenital inability to experience pain

http://www.wikidata.org/entity/Q28278844

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Progress in genetic studies of pain and analgesia A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome Transcriptional regulator PRDM12 is essential for human pain perception Channelopathies Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.Pain as a channelopathy Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons Structural determinants of drugs acting on the Nav1.8 channel Dynorphin, stress, and depression A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery Emerging preclinical pharmacological targets for Parkinson's disease Genetic neurological channelopathies: molecular genetics and clinical phenotypes.Primary erythromelalgia: a review Voltage-gated sodium channels and cancer: is excitability their primary role?Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels The perception and endogenous modulation of pain Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist Changing channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitability A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7 Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief Neurobiology: a channel sets the gain on pain A de novo gain-of-function mutation in SCN11A causes loss of pain perception Pain genes Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery Mouse DRG Cell Line with Properties of Nociceptors Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy Silencing the Kir4.1 potassium channel subunit in satellite glial cells of the rat trigeminal ganglion results in pain-like behavior in the absence of nerve injury In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin

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An SCN9A channelopathy causes congenital inability to experience pain

http://www.wikidata.org/entity/Q28278844

description

2006 nî lūn-bûn

@nan

2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

An SCN9A channelopathy causes congenital inability to experience pain

@ast

An SCN9A channelopathy causes congenital inability to experience pain

@en

An SCN9A channelopathy causes congenital inability to experience pain

@nl

type

label

An SCN9A channelopathy causes congenital inability to experience pain

@ast

An SCN9A channelopathy causes congenital inability to experience pain

@en

An SCN9A channelopathy causes congenital inability to experience pain

@nl

prefLabel

An SCN9A channelopathy causes congenital inability to experience pain

@ast

An SCN9A channelopathy causes congenital inability to experience pain

@en

An SCN9A channelopathy causes congenital inability to experience pain

@nl

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An SCN9A channelopathy causes congenital inability to experience pain

@en

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Adeline K Nicholas

http://www.w3.org/2001/XMLSchema#string

C Geoffrey Woods

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Duncan P McHale

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Emma Roberts

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Gemma Thornton

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Gulshan Karbani

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Henan Hamamy

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Hussain Jafri

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James J Cox

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John N Wood

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894-8

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scholarly article

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1138275

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10.1038/NATURE05413

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7121

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Lihadh Al-Gazali

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Fiona M Gribble

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2006-12-14T00:00:00Z

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1035659631

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17167479

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