Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain
about
Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of PainPharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations.The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling.Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats.Challenges to develop novel anti-inflammatory and analgesic drugs.Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways.Switching off pain at the source: is this the end for opioid pain relief?Breaking barriers to novel analgesic drug development.Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN): A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype.Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel.Use dependence of peripheral nociceptive conduction in the absence of tetrodotoxin-resistant sodium channel subtypes.Sodium channels in pain disorders: pathophysiology and prospects for treatment.Voltage-gated sodium channels: (NaV )igating the field to determine their contribution to visceral nociception.Sodium channels and pain: from toxins to therapies.Antinociceptive properties of shikonin: in vitro and in vivo studies.Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.Discovery of a Novel Na1.7 Inhibitor From Venom With Potent Analgesic Efficacy
P2860
Q28270611-9E2543C0-CC3B-41D2-B695-9115BF9E1EFCQ28548202-65301636-D000-4E63-BB70-D2A36A1471A4Q30835612-AC7A27C5-B669-47A7-89F4-95E130E91090Q33390819-C0415A53-C7BF-4CF8-A178-4C4C2F33544EQ35625713-277E48B6-3D80-4104-9FA3-F0ECB7F54076Q36258703-153A9C7E-520A-4915-BEA9-AFDC0A2270EFQ36281738-1AC89043-5BFF-4EF6-B427-93816D627FAAQ36941125-609F7CF4-F4CF-4DF7-BB85-D7E1677B3E82Q37461547-6C1FFC4C-A73C-4075-84E6-20ED24D4ABA2Q38941483-90E032E9-F1A3-43AC-A14F-63ABEE6798CFQ39010857-1A14BD54-E4F1-404F-8E40-334C32FB4EBFQ39179183-6DC5B974-3503-4E9B-B51E-98840441770BQ39360773-6DA716D3-D031-4F84-8106-62FC44B23EC7Q41661778-5AE18355-8697-4827-9CEA-38C26A1B9B7CQ41998701-86B827F5-87ED-4BC2-8FDA-3855F0692657Q45350259-A38A2BA1-81A6-4BD0-8520-D606392443ADQ46380475-2DDB378A-7FE7-4595-930E-597CEB3B1707Q47438395-39D12F43-208F-407E-B161-7AA1BA235269Q47959907-7BA576D1-CFFD-46E1-B6D8-19D91F2F278AQ48273674-AEBBD586-13C5-48D8-97E9-E8AB43B5A8AFQ48337085-321AA040-0930-4214-9451-CC95436A3C64Q51737604-8BA40587-F5CC-41F1-B6EF-B0F58C11D6B5Q55037976-4010F4A6-47C3-46D7-B391-4813EE6FA7E7Q58554174-C89B817B-178C-44F9-9FDF-F7D10E46A057
P2860
Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain
description
2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@ast
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@en
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@nl
type
label
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@ast
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@en
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@nl
prefLabel
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@ast
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@en
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@nl
P2093
P2860
P1433
P1476
Global Nav1.7 knockout mice re ...... ongenital indifference to pain
@en
P2093
Annika B Malmberg
Bryan D Moyer
Danielle Johnson
David J Matson
Elma Feric
Jacinthe Gingras
James B Rottman
Lauren Couture
Matthew L Peterson
P2860
P304
P356
10.1371/JOURNAL.PONE.0105895
P407
P577
2014-01-01T00:00:00Z