Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis - Wikidata - wikimedia - TriplyDB

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

http://www.wikidata.org/entity/Q28279683

about

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells Intrinsic disorder in spondins and some of their interacting partners.Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma.Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors.Analysis of LGR4 receptor distribution in human and mouse tissues Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating Wnt signal pathway.Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation.Acute and chronic regulation of aldosterone production.Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.GPR48 increases mineralocorticoid receptor gene expression.Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation.Multi-functional norrin is a ligand for the LGR4 receptor.Gene trap mutagenesis in mice: new perspectives and tools in cancer research.RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects.Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer.GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway.p27 modulates tropism of mesenchymal stem cells toward brain tumors.Stat3 upregulates leucine-rich repeat-containing g protein-coupled receptor 4 expression in osteosarcoma cells.GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma.Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide.Gnaq and Gna11 in the Endothelin Signaling Pathway and Melanoma.LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial-mesenchymal transition.LGR5 and LGR6 in stem cell biology and ovarian cancer.Upregulation of RSPO2-GPR48/LGR4 signaling in papillary thyroid carcinoma contributes to tumor progression.Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice.LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.

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P2860

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

http://www.wikidata.org/entity/Q28279683

description

2006 nî lūn-bûn

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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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0008-5472.CAN-06-2629

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Cancer Research

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Up-regulation of GPR48 induced ...... ll invasiveness and metastasis

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Chiharu Uchida

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Hirotoshi Kikuchi

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Hiroyuki Konno

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Keiichi I Nakayama

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Keiko Nakayama

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Kyoko Kitagawa

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Mai Shimada

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Masatoshi Kitagawa

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Takayuki Hattori

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Tatsuo Tanaka

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11623-31

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scholarly article

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2194408

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10.1158/0008-5472.CAN-06-2629

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24

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66

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2006-12-15T00:00:00Z

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17178856

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