Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation
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CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylationA functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumorsThe role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implicationsCullin family proteins and tumorigenesis: genetic association and molecular mechanismsA novel mutation in β integrin reveals an integrin-mediated interaction between the extracellular matrix and cki-1/p27KIP1Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility.Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremorCul4A is required for hematopoietic cell viability and its deficiency leads to apoptosisCul4B regulates neural progenitor cell growth.CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cellsCUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma.The role of cullin4B in human cancers.A protein network-guided screen for cell cycle regulators in Drosophila.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.Cullins and cancer.Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell deathmiR-221/222 compensates for Skp2-mediated p27 degradation and is a primary target of cell cycle regulation by prostacyclin and cAMPCullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis.14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation.The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complexStealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy.Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27MicroRNA transgene overexpression complements deficiency-based modifier screens in DrosophilaDNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitorsPathogenic Role of the CRL4 Ubiquitin Ligase in Human DiseaseCul4A is an oncogene in malignant pleural mesothelioma.Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex.Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication.The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation.Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.Proliferation defects and genome instability in cells lacking Cul4A.Timing is everything: consequences of transient and sustained AhR activity.CRL4s: the CUL4-RING E3 ubiquitin ligases.Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.Cif type III effector protein: a smart hijacker of the host cell cycle.
P2860
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P2860
Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@ast
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@en
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@nl
type
label
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@ast
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@en
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@nl
prefLabel
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@ast
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@en
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@nl
P2093
P356
P1433
P1476
Involvement of CUL4 ubiquitin ...... 7Kip1 and cyclin E degradation
@en
P2093
Damon Banks
Jianyu Zheng
Leigh Ann Higa
Papia Ghosh
Xiaoming Yang
P356
10.4161/CC.5.1.2266
P407
P577
2006-01-01T00:00:00Z