Proliferation defects and genome instability in cells lacking Cul4A. - Wikidata - wikimedia - TriplyDB

Proliferation defects and genome instability in cells lacking Cul4A.

Proliferation defects and genome instability in cells lacking Cul4A.

http://www.wikidata.org/entity/Q37249694

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Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth Cul4A is essential for spermatogenesis and male fertility.Transgenic mice for cre-inducible overexpression of the Cul4A gene.Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis.A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis.It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer.CRL4s: the CUL4-RING E3 ubiquitin ligases.Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response.CRL Ubiquitin Ligases and DNA Damage Response.The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity.Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.Knockdown of CUL4A inhibits invasion and induces apoptosis in osteosarcoma cells.

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Proliferation defects and genome instability in cells lacking Cul4A.

http://www.wikidata.org/entity/Q37249694

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 11 May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Proliferation defects and genome instability in cells lacking Cul4A.

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Proliferation defects and genome instability in cells lacking Cul4A.

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type

label

Proliferation defects and genome instability in cells lacking Cul4A.

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Proliferation defects and genome instability in cells lacking Cul4A.

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prefLabel

Proliferation defects and genome instability in cells lacking Cul4A.

@en

Proliferation defects and genome instability in cells lacking Cul4A.

@nl

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Proliferation defects and genome instability in cells lacking Cul4A.

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D Kopanja

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E Huang

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M N Okur

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P Raychaudhuri

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S Bagchi

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T Stoyanova

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p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes.

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scholarly article

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10.1038/ONC.2009.86

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2009-05-11T00:00:00Z

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