Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies
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Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymesEndocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibitionX-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide HydrolaseCrystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme InactivationFluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide HydrolaseReversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting AnalgesicsA Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide HydrolaseFatty acid amide hydrolase inhibitors: a patent review (2009-2014)Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disordersLatest advances in the discovery of fatty acid amide hydrolase inhibitorsApproximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapsesApplying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase.2012 Division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspectiveAdministration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol.An endocannabinoid mechanism for stress-induced analgesia.Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivoHippocampal metaplasticity is required for the formation of temporal associative memories.Molecular reorganization of endocannabinoid signalling in Alzheimer's diseaseDissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicleCellular viability effects of fatty acid amide hydrolase inhibition on cerebellar neuronsEffects of endocannabinoid system modulation on cognitive and emotional behaviorFood intake regulates oleoylethanolamide formation and degradation in the proximal small intestineAnandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding ModeRefined homology model of monoacylglycerol lipase: toward a selective inhibitor.Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic propertiesFurther advances in the synthesis of endocannabinoid-related ligands.The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibitionHemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability.Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.
P2860
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P2860
Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@ast
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@en
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@nl
type
label
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@ast
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@en
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@nl
prefLabel
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@ast
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@en
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@nl
P2093
P50
P356
P1476
Cyclohexylcarbamic acid 3'- or ...... and molecular modeling studies
@en
P2093
Andrea Duranti
Andrea Tontini
Daniele Piomelli
Giorgio Tarzia
Pier Vincenzo Plazzi
Satish Kathuria
P304
P356
10.1021/JM031140X
P407
P577
2004-10-01T00:00:00Z