A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions - Wikidata - wikimedia - TriplyDB

A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions

A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions

http://www.wikidata.org/entity/Q28287278

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API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis The paracaspase MALT1: biological function and potential for therapeutic inhibition Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma.Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.The CBM signalosome: potential therapeutic target for aggressive lymphoma?Oncogenic activation of NF-kappaB.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1.Molecular basis of lysophosphatidic acid-induced NF-κB activation Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation Inhibiting NF-κB activation by small molecules as a therapeutic strategy.MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-κB signaling.Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1).Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.BCL10GFP fusion protein as a substrate for analysis of determinants required for mucosa-associated lymphoid tissue 1 (MALT1)-mediated cleavage.IAP-targeted therapies for cancer.Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitme Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?Regulation of NF-κB signaling by caspases and MALT1 paracaspase.MALT lymphoma: many roads lead to nuclear factor-κb activation.MALT1 protease: a new therapeutic target in B lymphoma and beyond?Molecular pathogenesis and histologic and clinical features of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue type.Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies.MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.Roles of the NF-κB Pathway in B-Lymphocyte Biology.TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaB.IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy.Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions.The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex

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A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions

http://www.wikidata.org/entity/Q28287278

description

2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2007 թվականի ապրիլին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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A Novel TRAF6 binding site in ...... by API2middle dotMALT1 fusions

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Geert van Loo

http://www.w3.org/2001/XMLSchema#string

Heidi Noels

http://www.w3.org/2001/XMLSchema#string

Mathijs Baens

http://www.w3.org/2001/XMLSchema#string

Peter Marynen

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Sofie Hagens

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Vicky Broeckx

http://www.w3.org/2001/XMLSchema#string

P2860

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice

Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator

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10180-9

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scholarly article

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2372002

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10.1074/JBC.M611038200

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14

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282

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P577

2007-04-06T00:00:00Z

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6517995

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17287209

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