Overexpression of insulin receptor substrate 1 (IRS-1) in the human breast cancer cell line MCF-7 induces loss of estrogen requirements for growth and transformation

Overexpression of insulin receptor substrate 1 (IRS-1) in the human breast cancer cell line MCF-7 induces loss of estrogen requirements for growth and transformation

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http://www.wikidata.org/entity/Q28288872
Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumorsThe role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.Insulin receptor substrates (IRSs) and breast tumorigenesis.Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer.Detection of estrogen-independent growth-stimulating activity in breast cancer tissues: implication for tumor aggressivenessProtein kinase D1 regulates ERα-positive breast cancer cell growth response to 17β-estradiol and contributes to poor prognosis in patientsElevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases.Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.Expression of nuclear insulin receptor substrate 1 in breast cancer.Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only.Differential Expression of IRS-1 and IRS-2 in Uterine Leiomyosarcomas with Distinct Oncogenic Phenotypes: Lack of Correlation with Downstream Signaling Events.Targeting IGF1R pathway in cancer with microRNAs: How close are we ?Cryptotanshinone inhibition of mammalian target of rapamycin pathway is dependent on oestrogen receptor alpha in breast cancer.Revisiting the IGF-1R as a breast cancer target.
P2860

Overexpression of insulin receptor substrate 1 (IRS-1) in the human breast cancer cell line MCF-7 induces loss of estrogen requirements for growth and transformation

Item
http://www.wikidata.org/entity/Q28288872
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
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1995年論文
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1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
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1995年論文
@zh-tw
1995年论文
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name
Overexpression of insulin rece ...... for growth and transformation
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Overexpression of insulin rece ...... for growth and transformation
@en
Overexpression of insulin rece ...... for growth and transformation
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type
label
Overexpression of insulin rece ...... for growth and transformation
@ast
Overexpression of insulin rece ...... for growth and transformation
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Overexpression of insulin rece ...... for growth and transformation
@nl
prefLabel
Overexpression of insulin rece ...... for growth and transformation
@ast
Overexpression of insulin rece ...... for growth and transformation
@en
Overexpression of insulin rece ...... for growth and transformation
@nl
P1433
P1476
P2093
P304
P31
P407
P433
P478
P577
P698
P921
P1433
P1476
Overexpression of insulin rece ...... for growth and transformation
@en
P2093
P304
P31
P407
P433
P478
P577
P698
P921