Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2
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microRNA regulation of Wnt signaling pathways in development and diseaseThe Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated ProteinsInsulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9MHC-restricted phosphopeptides from insulin receptor substrate-2 and CDC25b offer broad-based immunotherapeutic agents for cancer.Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expressionIRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs.Gene expression profile during proliferation and differentiation of rainbow trout adipocyte precursor cells.Insulin receptor substrates (IRSs) and breast tumorigenesis.Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation.Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2.Signal transduction networks in cancer: quantitative parameters influence network topologyThe type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.MiR-570 inhibits cell proliferation and glucose metabolism by targeting IRS1 and IRS2 in human chronic myelogenous leukemia.The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKTImpact of diet-induced obesity on intestinal stem cells: hyperproliferation but impaired intrinsic function that requires insulin/IGF1Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling.Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathwaysThe insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer.Therapeutic destruction of insulin receptor substrates for cancer treatment.Whole exome sequencing of a single osteosarcoma case--integrative analysis with whole transcriptome RNA-seq data.Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage DifferentiationerbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines.Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.Association of Bactericidal Dysfunction of Paneth Cells in Streptozocin-Induced Diabetic Mice with Insulin DeficiencyInsulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells.TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cellsA regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer.The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer.Irs2 inactivation suppresses tumor progression in Pten+/- mice.Expression and function of the insulin receptor substrate proteins in cancerNovel insulin receptor substrate 1 and 2 variants in breast and colorectal cancerLack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancerCustomizing the targeting of IGF-1 receptor.IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivationHypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion.The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells.Targeting the insulin-like growth factor receptor: developing biomarkers from gene expression profiling.
P2860
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P2860
Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@ast
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@en
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@nl
type
label
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@ast
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@en
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@nl
prefLabel
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@ast
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@en
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@nl
P2093
P2860
P921
P3181
P356
P1476
Mammary tumorigenesis and meta ...... r substrate 1 (IRS-1) or IRS-2
@en
P2093
Adrian V Lee
D Craig Allred
Darryl L Hadsell
Hyun-Jung Kim
Isere Kuiatse
Jana Divisova
Nicole A Lawrence
Ora L Britton
Robert K Dearth
Syed Mohsin
P2860
P304
P3181
P356
10.1128/MCB.00260-06
P407
P577
2006-12-01T00:00:00Z