Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling - Wikidata - wikimedia - TriplyDB

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

http://www.wikidata.org/entity/Q28290286

about

Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture Serine 216 phosphorylation of estrogen receptor α in neutrophils: migration and infiltration into the mouse uterus The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.Phenobarbital Meets Phosphorylation of Nuclear Receptors Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium Small-molecule modulators of the constitutive androstane receptor.Small-molecule modulators of PXR and CAR.Deciphering the roles of the constitutive androstane receptor in energy metabolism.Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes.Phenobarbital and Insulin Reciprocate Activation of the Nuclear Receptor Constitutive Androstane Receptor through the Insulin Receptor.p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38.Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells.Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.Signaling control of the constitutive androstane receptor (CAR)Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.5-hydroxymethylcytosine profiling as an indicator of cellular state.Regulation of gene expression by CAR: an update.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Nuclear receptors and nonalcoholic fatty liver disease.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists.Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds.Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons.

P2860

Q28394850-6428D9A6-74E0-47CE-B7BA-0AA17FA18AC8 Q28538001-496157B6-D558-4597-97E6-81FCB106CA4A Q28542861-CF7CE40B-199B-4633-A912-D813E7EAD846 Q28554648-8F5C4909-4393-465A-97D0-C0B12A26476D Q33560278-72E0FDE6-2C52-40CF-9DCF-8DBEFBFF7FAF Q33588389-60B38F66-A9CA-4477-ADAD-4916FEDA9CB7 Q33606444-34DC7133-373A-4352-A745-6426757FFD10 Q33606475-AA8D308C-1EAB-47CA-B533-BC8468428CA0 Q33726321-800972FF-537F-4921-B447-1701508F198D Q35111456-8CB9B07F-0FD0-4A40-81B8-5CD9837ED145 Q35531860-F32438D5-C60D-4F76-B07E-16854F419F11 Q35575682-222C78D3-DE79-431D-B4E9-F5967293833E Q35748820-EC7A3632-AFE3-47E8-B398-81C7E5B954D2 Q35938150-A9A7BAAA-B972-4CD1-BF59-0710B6705912 Q36063700-F46C0F02-1B5C-4666-8DE4-250EDDA39721 Q36251418-D7AABB0C-7C7B-4553-AEF0-470EC716724F Q36325362-E5DAF59C-7281-4D1D-AEC3-76C02F93BF00 Q36382083-902F23BE-4910-4B01-9A66-58E7A98536B4 Q36737004-D365B24B-5E98-4471-AEFD-09D413FDE0CF Q36852579-E995B23E-5125-427C-A3BB-41D8D9D4BF49 Q36947710-858099B4-5E7C-40E3-9445-B2C80A318202 Q37014980-0281FC0C-DB50-48C0-8809-7B0AE1F53FEA Q37130938-B9897B65-D739-45D3-A0C5-A11EE12AFA6E Q37537458-B7D08DB0-10C2-456F-A3B6-1292ED80BF72 Q37537497-9ACB1B41-976B-434D-89FA-2E17294909A1 Q37553490-12C896DE-38E5-4FA5-A338-FDAA3CE27188 Q37642162-518EA7F6-6A92-40F0-8B86-CB476C566661 Q37701274-B3AF3AC8-93C0-4A63-96C8-D422F0728C3B Q38166838-BF8440EF-603C-474F-904C-57848879FD0C Q38481059-E6067FF6-77FA-430C-A2D3-C7EAD85C969E Q38733688-467F4C65-40AD-466B-ABCD-3CDC8886D076 Q38736787-2547FB41-DDAE-4C2A-9BEF-B570EE7C984F Q38750759-68E06095-FDE6-4C33-AC2E-8E332D9FAC0F Q38768048-C5971EB5-572F-4E40-8C8B-80B493597589 Q38854079-EB9882F5-211A-4C10-B489-532032C876A1 Q38883195-74B60178-F878-44F8-AAB8-FCA2A88A3CDF Q39031109-0E3C23B1-C5FB-4D1C-B892-B1B691F75693 Q39037022-D13DBDCD-A739-44A8-ACB7-15EBCA0EEC15 Q39747519-D53D5502-880E-42C3-904C-4BB81D7F2FDA Q40759673-E5A6A9AC-A093-4F65-A1A3-5D7FCEF2819A

P2860

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

http://www.wikidata.org/entity/Q28290286

description

2013 nî lūn-bûn

@nan

2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Phenobarbital indirectly activ ...... owth factor receptor signaling

@ast

Phenobarbital indirectly activ ...... owth factor receptor signaling

@en

Phenobarbital indirectly activ ...... owth factor receptor signaling

@nl

type

label

Phenobarbital indirectly activ ...... owth factor receptor signaling

@ast

Phenobarbital indirectly activ ...... owth factor receptor signaling

@en

Phenobarbital indirectly activ ...... owth factor receptor signaling

@nl

prefLabel

Phenobarbital indirectly activ ...... owth factor receptor signaling

@ast

Phenobarbital indirectly activ ...... owth factor receptor signaling

@en

Phenobarbital indirectly activ ...... owth factor receptor signaling

@nl

P1433

Q28290286-FF67E1FB-1982-403F-88AA-0073DAB60481

P1476

Q28290286-D42273AB-B99B-4151-BE1C-9BF99F8430A6

P2093

Q28290286-1A14046F-1654-49E3-9C7E-3CCF04DBE57A

Q28290286-315AD35C-2CAA-445E-96FC-5E3257B83A88

Q28290286-55CB39D8-D1F6-4D0D-83CA-99E603F611AF

Q28290286-AC6AC481-E0B9-43F9-9A74-B93D8E4E868C

Q28290286-DD99E7FC-BAB3-4D4E-BAC5-DE604EB6DC5F

Q28290286-DF818AB5-82CC-4E66-B634-5CDEE6FFF06B

Q28290286-F413DB69-1533-46F4-A2ED-5016BAA90518

P2860

Q28290286-0C952080-598C-42E0-87FA-4BBEC3C79119

Q28290286-1AD3F79E-1DFA-471D-B341-224E099C5F33

Q28290286-211DC447-4E65-4733-BBBB-9B0C51087ED9

Q28290286-27C1B736-5B24-4D20-A73F-E9409EE58A10

Q28290286-32CC5A28-BAF7-43F6-B993-C10325DB9C45

Q28290286-3623DD48-174F-40B3-9256-36C1DE6D7F15

Q28290286-57C168F3-235D-4922-9072-B5EA34EDAF62

Q28290286-59ED7A05-08A0-49B9-BACF-9A8A4A2F6150

Q28290286-5EAFA307-1453-45FF-962A-C83C87CEEF50

Q28290286-5F587AEE-40B6-4302-8EB8-B5C91703AAB5

P304

Q28290286-73F5D253-E361-40D3-9B26-35B65254D77B

P31

Q28290286-32871EE9-1E23-476E-8058-8764B2CE9BCA

P3181

Q28290286-4B956A47-52D6-4601-9852-9F1EDF4EE48E

P356

Q28290286-8A1ACAC8-2F32-49D5-8167-7386F4D4B3D4

P407

Q28290286-6937E0F8-BCD9-49A7-A43E-04F6338A89C0

P433

Q28290286-51D9FDFF-D090-4796-BC4D-B2D8E20534E0

P478

Q28290286-D825983A-AC72-4182-B946-C7238675DBA1

P577

Q28290286-F02F6121-3E59-4CB6-8A0E-7C95F1F3BDFA

P698

Q28290286-2D29EF2E-F3E2-4CC6-8B4A-193BD81A9D16

P932

Q28290286-A29F6DEA-C2E2-4932-AD92-79B52AA68A8F

P3181

P356

SCISIGNAL.2003705

P1433

Science Signaling

P1476

Phenobarbital indirectly activ ...... owth factor receptor signaling

@en

P2093

Lalith Perera

http://www.w3.org/2001/XMLSchema#string

Lee Pedersen

http://www.w3.org/2001/XMLSchema#string

Mack Sobhany

http://www.w3.org/2001/XMLSchema#string

Masahiko Negishi

http://www.w3.org/2001/XMLSchema#string

Rick Moore

http://www.w3.org/2001/XMLSchema#string

Shingo Mutoh

http://www.w3.org/2001/XMLSchema#string

Tatsuya Sueyoshi

http://www.w3.org/2001/XMLSchema#string

P2860

Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

PXR and CAR in energy metabolism

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

P304

ra31

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

683903

http://www.w3.org/2001/XMLSchema#string

P356

10.1126/SCISIGNAL.2003705

http://www.w3.org/2001/XMLSchema#string

P407

P433

274

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P577

2013-05-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23652203

http://www.w3.org/2001/XMLSchema#string

P932

5573139

http://www.w3.org/2001/XMLSchema#string