The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
about
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4ETuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingThe C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationmTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsExpression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayA variant mimicking hyperphosphorylated 4E-BP inhibits protein synthesis in a sea urchin cell-free, cap-dependent translation system.Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMPTranslation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform.Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitiRecombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E.Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A.The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translationmTOR signaling in lymphangioleiomyomatosisPhosphorylated p70S6K in noninvasive low-grade urothelial carcinoma of the bladder: correlation with tumor recurrence.mTOR controls ovarian follicle growth by regulating granulosa cell proliferationTherapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).Power of yeast for analysis of eukaryotic translation initiationReversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4FAn eIF4E-interacting peptide induces cell death in cancer cell lines.Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibitionEffect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway.P70S6K and Elf4E dual inhibition is essential to control bladder tumor growth and progression in orthotopic mouse non-muscle invasive bladder tumor model.Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos.Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazoleCoupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cellsPost-transcriptional regulation in cancer progression : Microenvironmental control of alternative splicing and translation.Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment.Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformationReduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein.Small-Molecule targeting of translation initiation for cancer therapy.Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by Src and protein phosphatase 2A (PP2A) on extracellular matrixSynthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interactionCap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype.In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.Cell cycle progression and proliferation despite 4BP-1 dephosphorylation.Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta.
P2860
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P2860
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@ast
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@en
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@nl
type
label
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@ast
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@en
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@nl
prefLabel
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@ast
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@en
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@nl
P2093
P1433
P1476
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
@en
P2093
P304
P407
P577
1996-12-01T00:00:00Z