Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues
about
Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activityLigand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.Tobacco budworm dihydrofolate reductase is a promising target for insecticide discovery.Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophiliaExploiting ligand-protein conjugates to monitor ligand-receptor interactions.Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors.Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexateSearching sequence space: two different approaches to dihydrofolate reductase catalysis.From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates.A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiaeMethotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes.Mechanism of inhibition of wt-dihydrofolate reductase from E. coli by tea epigallocatechin-gallate.A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase.A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.Warfarin and vitamin K compete for binding to Phe55 in human VKOR.Reduced susceptibility of Moritella profunda dihydrofolate reductase to trimethoprim is not due to glutamate 28.Titration of Folate Pathway Enzymes
P2860
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P2860
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues
description
1986 nî lūn-bûn
@nan
1986 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
Mechanism of inhibition of dih ...... us classes of folate analogues
@ast
Mechanism of inhibition of dih ...... us classes of folate analogues
@en
Mechanism of inhibition of dih ...... us classes of folate analogues
@nl
type
label
Mechanism of inhibition of dih ...... us classes of folate analogues
@ast
Mechanism of inhibition of dih ...... us classes of folate analogues
@en
Mechanism of inhibition of dih ...... us classes of folate analogues
@nl
prefLabel
Mechanism of inhibition of dih ...... us classes of folate analogues
@ast
Mechanism of inhibition of dih ...... us classes of folate analogues
@en
Mechanism of inhibition of dih ...... us classes of folate analogues
@nl
P1476
Mechanism of inhibition of dih ...... us classes of folate analogues
@en
P2093
J F Morrison
P304
P356
10.1016/0167-4838(86)90067-1
P407
P577
1986-02-14T00:00:00Z