Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity - Wikidata - wikimedia - TriplyDB

Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity

Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity

http://www.wikidata.org/entity/Q27653751

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Kinetic and Structural Characterization of Dihydrofolate Reductase from Streptococcus pneumoniae Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1 Structure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase Newer antibacterial drugs for a new century.Postgenomic strategies in antibacterial drug discovery.Antifolate agents: a patent review (2006 - 2010).A docking-based receptor library of antibiotics and its novel application in predicting chronic mixture toxicity for environmental risk assessment.Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis Protein design algorithms predict viable resistance to an experimental antifolate Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.Winning the arms race by improving drug discovery against mutating targets.Antibiotic resistance in Staphylococcus aureus. Current status and future prospects.Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.Recent Advances in the Rational Design and Optimization of Antibacterial Agents.Emergence of trimethoprim resistance gene dfrG in Staphylococcus aureus causing human infection and colonization in sub-Saharan Africa and its import to Europe.MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.In vitro bactericidal activity of iclaprim in human plasma.Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates.The challenge of developing robust drugs to overcome resistance.An Updated Review of Iclaprim: A Potent and Rapidly Bactericidal Antibiotic for the Treatment of Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Gram-Positive Including Multidrug-Resistant Bacteria.Magnetic nanoparticles for direct protein sorting inside live cells

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Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity

http://www.wikidata.org/entity/Q27653751

description

2009 nî lūn-bûn

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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Increased hydrophobic interact ...... ity and antibacterial activity

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Increased hydrophobic interact ...... ity and antibacterial activity

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Increased hydrophobic interact ...... ity and antibacterial activity

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Increased hydrophobic interact ...... ity and antibacterial activity

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Increased hydrophobic interact ...... ity and antibacterial activity

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Increased hydrophobic interact ...... ity and antibacterial activity

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prefLabel

Increased hydrophobic interact ...... ity and antibacterial activity

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Increased hydrophobic interact ...... ity and antibacterial activity

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Increased hydrophobic interact ...... ity and antibacterial activity

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Journal of Antimicrobial Chemotherapy

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Increased hydrophobic interact ...... ity and antibacterial activity

@en

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Andreas Haldimann

http://www.w3.org/2001/XMLSchema#string

Christian Oefner

http://www.w3.org/2001/XMLSchema#string

Glenn E Dale

http://www.w3.org/2001/XMLSchema#string

Heike Laue

http://www.w3.org/2001/XMLSchema#string

Henk Schulz

http://www.w3.org/2001/XMLSchema#string

Laurent Weiss

http://www.w3.org/2001/XMLSchema#string

Monica Bandera

http://www.w3.org/2001/XMLSchema#string

Sandro Parisi

http://www.w3.org/2001/XMLSchema#string

Seema Mukhija

http://www.w3.org/2001/XMLSchema#string

Sergio Lociuro

http://www.w3.org/2001/XMLSchema#string

P2860

Structure and function of the dihydropteroate synthase from Staphylococcus aureus

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

Refinement of macromolecular structures by the maximum-likelihood method

The CCP4 suite: programs for protein crystallography

Structure, dynamics, and catalytic function of dihydrofolate reductase

Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues

Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).

Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria.

DNA and RNA synthesis: antifolates.

Trimethoprim-sulfamethoxazole as a viable treatment option for infections caused by methicillin-resistant Staphylococcus aureus.

P304

687-98

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scholarly article

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10.1093/JAC/DKP024

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4

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63

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2009-04-01T00:00:00Z

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24002671

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19211577

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