Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling - Wikidata - wikimedia - TriplyDB

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

http://www.wikidata.org/entity/Q28301000

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Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation The TLR and IL-1 signalling network at a glance Recent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4 Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity IRAK-4 inhibitors for inflammation Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge.IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection.Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines.Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation.Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses.Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers Temozolomide-modulated glioma proteome: role of interleukin-1 receptor-associated kinase-4 (IRAK4) in chemosensitivity.The critical role of IL-1 receptor-associated kinase 4-mediated NF-κB activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis.IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease.The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation.IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation Comprehensive genomic profiling in diabetic nephropathy reveals the predominance of proinflammatory pathways.Innate immunity to virus infection.Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold.Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity.Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.Inhibition of the type I interferon antiviral response during arenavirus infection.Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants.Regulation of TLR7/9 signaling in plasmacytoid dendritic cells.Role of CD14 in host protection against infections and in metabolism regulation.Rare mendelian primary immunodeficiency diseases associated with impaired NF-κB signaling Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection.TLR9-based immunotherapy for the treatment of allergic diseases.Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation.Deficiency in IRAK4 activity attenuates manifestations of murine Lupus.

P2860

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

http://www.wikidata.org/entity/Q28301000

description

2007 nî lūn-bûn

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2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2007 թվականի մայիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Essential role of IRAK-4 prote ...... onses but not in TCR signaling

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Essential role of IRAK-4 prote ...... onses but not in TCR signaling

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Essential role of IRAK-4 prote ...... onses but not in TCR signaling

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type

label

Essential role of IRAK-4 prote ...... onses but not in TCR signaling

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Essential role of IRAK-4 prote ...... onses but not in TCR signaling

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Essential role of IRAK-4 prote ...... onses but not in TCR signaling

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prefLabel

Essential role of IRAK-4 prote ...... onses but not in TCR signaling

@ast

Essential role of IRAK-4 prote ...... onses but not in TCR signaling

@en

Essential role of IRAK-4 prote ...... onses but not in TCR signaling

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P1433

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Journal of Experimental Medicine

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Essential role of IRAK-4 prote ...... onses but not in TCR signaling

@en

P2093

Andreas Jung

http://www.w3.org/2001/XMLSchema#string

Hiroki Kato

http://www.w3.org/2001/XMLSchema#string

Kosuke Matsui

http://www.w3.org/2001/XMLSchema#string

Masahiro Yamamoto

http://www.w3.org/2001/XMLSchema#string

Osamu Takeuchi

http://www.w3.org/2001/XMLSchema#string

Satoshi Uematsu

http://www.w3.org/2001/XMLSchema#string

Shintaro Sato

http://www.w3.org/2001/XMLSchema#string

Tatsukata Kawagoe

http://www.w3.org/2001/XMLSchema#string

P2860

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

A Toll-like receptor recognizes bacterial DNA

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses

IRAK-M is a negative regulator of Toll-like receptor signaling

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

Innate immune recognition

Pathogen recognition and innate immunity

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1013-24

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scholarly article

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10.1084/JEM.20061523

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5

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P478

204

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2007-05-14T00:00:00Z

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6344933

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P698

17485511

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P921

Toll-like receptor

P932

2118579

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