Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization
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Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteinsGPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexesDuration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activationThe R7 RGS protein family: multi-subunit regulators of neuronal G protein signalingMu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling.The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins.Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine.An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptorsHow regulators of G protein signaling achieve selective regulation.A finer tuning of G-protein signaling through regulated control of RGS proteins.Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent morphine antinociception.Structure, function, and localization of Gβ5-RGS complexes.Control of striatal signaling by g protein regulators.Nitric oxide and zinc-mediated protein assemblies involved in mu opioid receptor signaling.The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targetingGz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain.The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.Oxidative stress induced by morphine in brain of rats fed with a protein deficient diet.Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain.The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation.The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
P2860
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P2860
Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization
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2005 nî lūn-bûn
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2005 թուականի Մարտին հրատարակուած գիտական յօդուած
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2005 թվականի մարտին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年论文
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name
Activation of mu-opioid recept ...... le in receptor desensitization
@ast
Activation of mu-opioid recept ...... le in receptor desensitization
@en
Activation of mu-opioid recept ...... le in receptor desensitization
@nl
type
label
Activation of mu-opioid recept ...... le in receptor desensitization
@ast
Activation of mu-opioid recept ...... le in receptor desensitization
@en
Activation of mu-opioid recept ...... le in receptor desensitization
@nl
prefLabel
Activation of mu-opioid recept ...... le in receptor desensitization
@ast
Activation of mu-opioid recept ...... le in receptor desensitization
@en
Activation of mu-opioid recept ...... le in receptor desensitization
@nl
P50
P356
P1476
Activation of mu-opioid recept ...... le in receptor desensitization
@en
P2093
Almudena López-Fando
P304
P356
10.1074/JBC.M407005200
P407
P577
2005-01-04T00:00:00Z