Exosite-driven substrate specificity and function in coagulation
about
The role of saliva in tick feedingStructure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active SiteAllosteric regulation of rhomboid intramembrane proteolysisA quantitative method for the specific assessment of caspase-6 activity in cell cultureContribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase,Structure of BbKI, a disulfide-free plasma kallikrein inhibitor.Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae).Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC.A sequence and structure based method to predict putative substrates, functions and regulatory networks of endo proteases.An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinaseRegulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrateProteomic profiling of proteases: tools for granzyme degradomics.A revisit to the one form kinetic model of prothrombinaseRatcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase.Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.Inhibition of thrombin formation by active site mutated (S360A) activated protein C.Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa.Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIaEmerging principles in protease-based drug discovery.The molecular basis of factor V and VIII procofactor activationSulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIaAlboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activityDeterminants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombinIdentification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cellsAllosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants.Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function.The structure of thrombin, a chameleon-like proteinase.Targeting exosites on blood coagulation proteases.P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombinLufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivoIxolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite.Determinants of specificity in coagulation proteases.A sequential mechanism for exosite-mediated factor IX activation by factor XIaRestricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.Kallikreins - The melting pot of activity and functionRole of Na+ and K+ in enzyme function.
P2860
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P2860
Exosite-driven substrate specificity and function in coagulation
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Exosite-driven substrate specificity and function in coagulation
@ast
Exosite-driven substrate specificity and function in coagulation
@en
Exosite-driven substrate specificity and function in coagulation
@nl
type
label
Exosite-driven substrate specificity and function in coagulation
@ast
Exosite-driven substrate specificity and function in coagulation
@en
Exosite-driven substrate specificity and function in coagulation
@nl
prefLabel
Exosite-driven substrate specificity and function in coagulation
@ast
Exosite-driven substrate specificity and function in coagulation
@en
Exosite-driven substrate specificity and function in coagulation
@nl
P2860
P1476
Exosite-driven substrate specificity and function in coagulation
@en
P2093
S Krishnaswamy
P2860
P356
10.1111/J.1538-7836.2004.01021.X
P407
P577
2005-01-01T00:00:00Z