Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)
about
Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functionsScurfin (FOXP3) acts as a repressor of transcription and regulates T cell activationCDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factorNew insight into the molecular mechanisms of MLL-associated leukemiaInhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologuesMLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein functionRegulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteinsRegulation of nuclear translocation of forkhead transcription factor AFX by protein kinase BExpression of Drosophila FOXO regulates growth and can phenocopy starvationThe Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingCrystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modificationStructural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational ModificationLigand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor familyEstrogen regulation of Pak1 and FKHR pathways in breast cancer cellsAn mRNA splice variant of the AFX gene with altered transcriptional activityThe FoxO codeConstitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicityT(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphomaMetformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cellsFoxO3a is activated and executes neuron death via Bim in response to β-amyloidFOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stressProtein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1FOXO transcription factors at the interface between longevity and tumor suppressionFoxO mediates APP-induced AICD-dependent cell death.RNAi screening for kinases and phosphatases identifies FoxO regulatorsUsing cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation.Monosomy X as the sole cytogenetic abnormality in acute lymphoblastic leukemia: a report of two new patients.FOXOs, cancer and regulation of apoptosisSulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain.The FoxO family in cardiac function and dysfunction.Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol.MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomForkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23).FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.
P2860
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P2860
Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@ast
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@en
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@nl
type
label
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@ast
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@en
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@nl
prefLabel
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@ast
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@en
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@nl
P2093
P3181
P356
P1433
P1476
Cloning and characterization o ...... kemias with a t(X;11)(q13;q23)
@en
P2093
A Borkhardt
J Hammermann
P2888
P304
P3181
P356
10.1038/SJ.ONC.1200814
P407
P577
1997-01-16T00:00:00Z
P5875
P6179
1024647657