MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1
about
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesisSynthetic lethality in lung cancer and translation to clinical therapiesGenome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF ComplexesGenetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancerThe SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell ProliferationAlgorithms for network-based identification of differential regulators from transcriptome data: a systematic evaluationMAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myelomaMolecular pathways and therapeutic targets in lung cancerMeta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy.MYC Deregulation in Primary Human Cancers.Expression inactivation of SMARCA4 by microRNAs in lung tumorsSystems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer.Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case.Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers.Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas.Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation.Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAXLinking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer.MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation.MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.A rationale to target the SWI/SNF complex for cancer therapy.Vulnerabilities of mutant SWI/SNF complexes in cancer.Chromatin remodeler mutations in human cancers: epigenetic implications.Molecular Pathogenesis and Targeted Therapy of Pancreatic Cancer.Lineage factors and differentiation states in lung cancer progression.Cell adhesion and polarity in squamous cell carcinoma of the lung.BRG1 regulation by miR-155 in human leukemia and lymphoma cell lines.SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development.Marked for death: targeting epigenetic changes in cancer.SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer.Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).Roles of pRB in the Regulation of Nucleosome and Chromatin Structures.c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinomaGenomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway.Hypoxia reduces MAX expression in endothelial cells by unproductive splicing.Induction of functional Brm protein from Brm knockout miceSWI/SNF proteins as targets in cancer therapy.Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.miRNA‑1284 inhibits cell growth and induces apoptosis of lung cancer cells.
P2860
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P2860
MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@ast
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@en
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@nl
type
label
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@ast
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@en
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@nl
prefLabel
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@ast
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@en
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@nl
P2093
P50
P3181
P1433
P1476
MAX inactivation in small cell ...... is synthetic lethal with BRG1
@en
P2093
Alberto Villanueva
Antonio Gomez
Jun Yokota
Luis M Montuenga
Reika Iwakawa
Takashi Kohno
P304
P3181
P356
10.1158/2159-8290.CD-13-0799
P407
P577
2013-12-20T00:00:00Z