NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
about
Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary callsCloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutationsThe X-ray structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase fromSaccharomyces cerevisiaeMitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryosMammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissuesDeletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in miceMetabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues.Disruption of the folate pathway in zebrafish causes developmental defectsMitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic developmentAnalysis of the promoter region of the gene encoding NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolaseThe folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoformContribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cellsThe effect of mitochondrial dysfunction on cytosolic nucleotide metabolism.Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development.Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase.Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation
P2860
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P2860
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
description
1985 nî lūn-bûn
@nan
1985 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@ast
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@en
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@nl
type
label
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@ast
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@en
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@nl
prefLabel
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@ast
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@en
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@nl
P1476
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
@en
P2093
R E MacKenzie
P304
P407
P577
1985-11-25T00:00:00Z