Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development
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Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatmentHuman mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary callsBiomarkers of Nutrition for Development-Folate ReviewModeling cellular compartmentation in one-carbon metabolismMitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryosMammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissuesDeletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in miceMitochondrial dysfunction remodels one-carbon metabolism in human cellsMagnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1.The role of mitochondrial DNA copy number in mammalian fertility.Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Disruption of the folate pathway in zebrafish causes developmental defectsFolic acid in early pregnancy: a public health success storyDisruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria.Unraveling the association between mRNA expressions and mutant phenotypes in a genome-wide assessment of mice.Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate PathwayLeber hereditary optic neuropathy: do folate pathway gene alterations influence the expression of mitochondrial DNA mutation?Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.Genetic and epigenomic footprints of folate.Trafficking of intracellular folates.Mitochondrial one-carbon metabolism and neural tube defects.Give it or take it: the flux of one-carbon in cancer cells.One-Carbon Metabolism in Health and Disease.Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs.Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans.The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism.Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia.Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.Increased formate overflow is a hallmark of oxidative cancer.Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translationInsights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies
P2860
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P2860
Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development
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2002 nî lūn-bûn
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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2002 թվականի հունիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
Mitochondrial NAD-dependent me ...... tial for embryonic development
@ast
Mitochondrial NAD-dependent me ...... tial for embryonic development
@en
Mitochondrial NAD-dependent me ...... tial for embryonic development
@nl
type
label
Mitochondrial NAD-dependent me ...... tial for embryonic development
@ast
Mitochondrial NAD-dependent me ...... tial for embryonic development
@en
Mitochondrial NAD-dependent me ...... tial for embryonic development
@nl
prefLabel
Mitochondrial NAD-dependent me ...... tial for embryonic development
@ast
Mitochondrial NAD-dependent me ...... tial for embryonic development
@en
Mitochondrial NAD-dependent me ...... tial for embryonic development
@nl
P2093
P2860
P1476
Mitochondrial NAD-dependent me ...... tial for embryonic development
@en
P2093
Di Pietro E
MacKenzie RE
Tremblay ML
P2860
P304
P356
10.1128/MCB.22.12.4158-4166.2002
P407
P577
2002-06-01T00:00:00Z