In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament - Wikidata - wikimedia - TriplyDB

In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament

In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament

http://www.wikidata.org/entity/Q28307598

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Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C Animal and in silico models for the study of sarcomeric cardiomyopathies Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor Protein glutathionylation in cardiovascular diseases Structural Insight into Unique Cardiac Myosin-binding Protein-C Motif: A PARTIALLY FOLDED DOMAIN MYBPC1, an Emerging Myopathic Gene: What We Know and What We Need to Learn Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy How do MYBPC3 mutations cause hypertrophic cardiomyopathy?Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties Determination of the critical residues responsible for cardiac myosin binding protein C's interactions Loss of actomyosin regulation in distal arthrogryposis myopathy due to mutant myosin binding protein-C slow.In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy.Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain.The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.Molecular modeling of disease causing mutations in domain C1 of cMyBP-C Cardiac myosin binding protein-C: a novel sarcomeric target for gene therapy Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype.Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling.Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy.Myosin binding protein-C: a regulator of actomyosin interaction in striated muscle Oxidative proteome alterations during skeletal muscle ageing Cardiac myosin binding protein C insufficiency leads to early onset of mechanical dysfunction.Modulation of striated muscle contraction by binding of myosin binding protein C to actin.Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle Cardiac myosin binding protein-C: redefining its structure and function.Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif.Molecular mechanics of cardiac myosin-binding protein C in native thick filaments.Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function.Slowing of contractile kinetics by myosin-binding protein C can be explained by its cooperative binding to the thin filament.In vivo cardiac myosin binding protein C gene transfer rescues myofilament contractile dysfunction in cardiac myosin binding protein C null mice Cross-species mechanical fingerprinting of cardiac myosin binding protein-C

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In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament

http://www.wikidata.org/entity/Q28307598

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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In the thick of it: HCM-causin ...... proteins of the thick filament

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CIRCRESAHA.110.231670

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Circulation Research

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In the thick of it: HCM-causin ...... proteins of the thick filament

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Kristina L Bezold

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Ross G Lyons

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Samantha P Harris

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P2860

Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C

Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation

Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy

Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle

Dissecting the N-terminal myosin binding site of human cardiac myosin-binding protein C. Structure and myosin binding of domain C2

The interaction of C-protein with heavy meromyosin and subfragment-2

Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein

Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?

A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia

Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations

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