Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro
about
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivoDifferential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurineAntiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenineSynthesis and biological activities of new carbaacyclonucleosides and 1'-oxaacyclonucleosides related to clitocine.The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.Selective inhibition of human papillomavirus-induced cell proliferation by (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosineActivation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1alpha) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1beta) production.Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.Synthesis of conformationally locked L-deoxythreosyl phosphonate nucleosides built on a bicyclo[3.1.0]hexane template.A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs.Update on new antivirals under development for the treatment of double-stranded DNA virus infectionsSerine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activityGS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.Synthesis and Biological Evaluation of 9-Deazaadenine 5'-Deoxy-6',6'-Difluoro-Carbocyclic C-Nucleoside Phosphonic Acid Derivatives.Synthesis and potent anti-leukemic activity of novel 5'-deoxycarbocyclic C-nucleoside phosphonic acids.Synthesis of Novel 4'-Trifluoromethyl-5'-Norcarbocyclic C-Nucleoside Phosphonic Acids as Potent Anti-Leukemic Agents.Efficient electrophilic fluorination for the synthesis of novel 2'-fluoro-3'-methyl-5'-deoxyphosphonic acid apiosyl nucleoside analogues.Design and synthesis of novel 1',3'-dioxolane 5'-deoxyphosphonic acid purine analogues as potent antiviral agents.Disposition of the acyclic nucleoside phosphonate (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonatesAntivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures.Rat cytomegalovirus-induced pneumonitis after allogeneic bone marrow transplantation: effective treatment with (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosineComparative activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against rat cytomegalovirus infection in vitro and in vivo.Synthesis of acyclic nucleoside phosphonates.Synthesis of novel 2',3'-difluorinated 5'-deoxythreosyl phosphonic acid nucleosides as antiviral agents.The first synthesis of 4'-branched 5'-deoxycarbocyclic 9-deazaadenosine and phosphonic acids as antiviral agents.Synthesis and antiviral evaluation of novel 4'-trifluoromethylated 5'-deoxyapiosyl nucleoside phosphonic acids.Synthesis and antiretroviral activity of novel 4'-fluoro-5'-deoxyphosphonic acid carbocyclic nucleoside analogs.Synthesis of novel 2'-fluoro-3'-hydroxymethyl-5'-deoxythreosyl phosphonic acid nucleoside analogues as antiviral agents.Synthesis and antiviral evaluation of novel 2',2'-difluoro 5'-norcarbocyclic phosphonic acid nucleosides as antiviral agents.Design and synthesis of novel threosyl-5'- deoxyphosphonic acid purine analogues as potent anti-HIV agents.Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.Efficacy and adverse effects of (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine in feline immunodeficiency virus-infected cats.Effects of Aspergillus terreus extract on herpes simplex 1 virus replication.Multifunctional viral protein γ34.5 manipulates nucleolar protein NOP53 for optimal viral replication of HSV-1.Synthesis and evaluation of novel 6',6'-difluoro 5'-deoxycarbocyclic phosphonic acid nucleosides as antiviral agents.
P2860
Q28316183-DA4C796C-9674-4A8B-B2CF-F40AD11B46D1Q28323877-D0669E0D-F410-4FC4-9B37-795FE1F6DD56Q28368376-F2149942-976F-449A-85B6-EED7D076D4D3Q28378681-F12ED0CC-1EF1-49B5-86FF-FCCE2A7B0C8FQ28379083-0397BAE6-984B-4D3F-9121-DC9B1581CD29Q31393121-D8B0E491-573A-4777-B858-180E7AF1FF58Q33782538-0C8FE66D-EE0A-4B6D-A2D5-B1B2DCCD99ECQ33976303-806F7B32-525D-4C63-8944-E31B3664C0ABQ33983556-5BAF4354-B064-42B3-AF7E-9A6954A66048Q34230702-5BD83A13-41BB-41D5-B7A1-2F94FA8403B8Q34586787-960AAB3C-5C63-48FD-A981-D880365F24D1Q35807437-C1135ADB-8439-4481-A769-7EC1EC64DD4CQ35903936-89301A6C-BB5C-4522-9119-D603EE24DFF5Q36185647-8D6B2D7A-7531-47CD-A4C6-52BC2F636FA3Q37069884-1C70C3C1-3CC2-4FB8-BBBA-D98ED542EBF0Q37247715-ECBE77AC-F86B-46C2-873B-74B30D99C569Q37450784-168CDD44-676E-49A9-ACE9-02FE52CC2A5FQ38827914-2308EED5-157D-4AD0-B599-A5DB552EAB11Q38833158-F6954569-6F20-44D6-A2C9-E33B9932CCF3Q38833361-A93761E4-2D0F-4067-811E-566623CBEF2CQ39078936-B71398A1-4670-4987-995F-65E3D9B0AA61Q39401909-39E1EA5E-C1A0-4244-9940-496FE222ADFFQ39558455-7B9D4EB0-6F33-466E-9A7F-BB731EA5F142Q39652313-55934C3B-9DF3-446F-AE06-06AF6C68DFF8Q39657990-3373399E-C5CB-4C13-AA9B-146A00951B17Q39864931-83895BB0-C38E-49FF-9E2D-1997E2454BCEQ40087953-2A792DCF-33ED-409E-A44B-09AE35D7A0E1Q40100237-439D3522-1DB7-45B6-9CE3-36D1CF235A64Q41522072-0D80C6A6-9060-4C7F-892E-13FD191F929CQ42160280-B06711AB-7D2D-43E5-B218-82510C08C4BFQ42182127-AB266DF3-8DF8-45C5-8FCF-5AADF2C92877Q42187954-A9BD8C67-BF20-4E9A-ADC3-986394695AE2Q42229526-1D7E6559-AC3A-4BBF-90DB-33F5CC23C5A2Q42234101-40382F63-3DAA-4495-8DB2-6C05006F8B5AQ42718928-DC99A4EB-0499-4D9D-89F6-0FA036856EA2Q43639401-4B1FE09E-5516-460C-85B7-6E74747EFCE5Q45354471-A9CFCA33-6587-4EA0-B975-A6531E8F8F3AQ45787770-DC22286C-0F50-481E-864C-B3F43070482AQ47549132-46D42CF4-ECE8-4437-BD1A-CE3F4E45892DQ51872819-5A3EFFF1-3D67-4DD0-8BCB-7849F9E8E83E
P2860
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro
description
1990 nî lūn-bûn
@nan
1990 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@ast
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@en
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@nl
type
label
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@ast
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@en
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@nl
prefLabel
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@ast
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@en
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@nl
P2093
P50
P1433
P1476
Acyclic nucleotide analogues: ...... virus-encoded enzymes in vitro
@en
P2093
H Hrebabecký
I Rosenberg
P304
P356
10.1016/0166-3542(90)90014-X
P407
P577
1990-06-01T00:00:00Z