Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
about
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replicationAntiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapyAn Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A RepliconsInhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue cultureAnti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPAAntiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newbAntiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in miceThe lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applicationsA multi-targeted drug candidate with dual anti-HIV and anti-HSV activityTenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gelPharmacokinetics and bioavailability of the anti-human immunodeficiency virus nucleotide analog 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatmentAntiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques.Single-dose and steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected children.Prodrug and antedrug: two diametrical approaches in designing safer drugs.Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.New approaches in the management of chronic hepatitis B: role of tenofovir.Blocking premature reverse transcription fails to rescue the HIV-1 nucleocapsid-mutant replication defect.One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidatesTyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studiesAlpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action.Antiviral therapy for human immunodeficiency virus infectionsIn search of a selective antiviral chemotherapy.Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs.Molecular umbrellas: a novel class of candidate topical microbicides to prevent human immunodeficiency virus and herpes simplex virus infectionsSR-2P vaginal microbicide gel provides protection against herpes simplex virus 2 when administered as a combined prophylactic and postexposure therapeuticIntravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infectionIn Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate.Potential role of tenofovir vaginal gel for reduction of risk of herpes simplex virus in femalesA drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infectionTenofovir resistance and resensitizationMicrobicides: still a long road to successThe discovery of antiviral agents: ten different compounds, ten different stories.Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivoEnantiomeric radiochemical synthesis of R and S (1-(6-amino-9H-purin-9-yl)-3-fluoropropan-2-yloxy)methylphosphonic acid (FPMPA)
P2860
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P2860
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
description
1993 nî lūn-bûn
@nan
1993 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@ast
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@en
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@nl
type
label
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@ast
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@en
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@nl
prefLabel
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@ast
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@en
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@nl
P2093
P2860
P50
P356
P1476
Differential antiherpesvirus a ...... thoxypropyl)-2,6-diaminopurine
@en
P2093
P2860
P356
10.1128/AAC.37.2.332
P407
P577
1993-02-01T00:00:00Z