Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) in rats
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Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression.Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays.Morphological transformation and catalase activity of Syrian hamster embryo cells treated with hepatic peroxisome proliferators, TPA and nickel sulphateA carcinogenic potency database of the standardized results of animal bioassays.Regulation of lipid and lipoprotein metabolism by PPAR activators.Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism.Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanismsHepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk.Mitochondrial toxicity of phthalate esters.Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensingSuccessful drug development despite adverse preclinical findings part 2: examples.Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findingsPPARalpha agonist-induced rodent tumors: modes of action and human relevance.Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid.Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout.Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.Possible mechanisms in hepatocarcinogenesis by the peroxisome proliferator di(2-ethylhexyl)phthalate.Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants.The effect of peroxisome proliferators on microsomal, peroxisomal, and mitochondrial enzyme activities in the liver and kidney.Incidence of pancreatic tumors and tumor precursors in Sprague-Dawley rats after administration of olive oil.The potential role of chemically induced hyperplasia in the carcinogenic activity of the hypolipidemic carcinogens.Studies of pancreatic carcinogenesis in different animal models.Hepatic and renal effects of peroxisome proliferators: biological implications.Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis.Liver carcinogenesis is not a predicted outcome of chemically induced hepatocyte proliferation.The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture.Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.Immunohistochemical demonstration of the gap junctional protein connexin 32 and proliferating cell nuclear antigen in glutathione S-transferase placental form-negative lesions of rat liver induced by diethylnitrosamine and clofibrate.The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions.Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.Effects of commercial chlorophenolate, 2,3,7,8-TCDD, and pure phenoxyacetic acids on hepatic peroxisome proliferation, xenobiotic metabolism and sister chromatid exchange in the rat.Peroxisome proliferators show tumor-promoting but no direct transforming activity in vitro.
P2860
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P2860
Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) in rats
description
1979 nî lūn-bûn
@nan
1979 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1979 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
name
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@ast
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@en
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@nl
type
label
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@ast
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@en
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@nl
prefLabel
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@ast
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@en
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@nl
P2860
P356
P1476
Tumorigenicity of the hypolipi ...... obutyrate (clofibrate) in rats
@en
P2093
S A Qureshi
P2860
P2888
P304
P356
10.1038/BJC.1979.203
P407
P577
1979-09-01T00:00:00Z
P5875
P6179
1040757771