Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins - Wikidata - wikimedia - TriplyDB

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

http://www.wikidata.org/entity/Q28343954

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Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1 Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1 The EHEC-host interactome reveals novel targets for the translocated intimin receptor Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)Identification of post-transcriptionally regulated Xenopus tropicalis maternal mRNAs by microarray The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers The Non-Canonical Role of Aurora-A in DNA Replication Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores A cell cycle timer for asymmetric spindle positioning The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast.Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.Inhibition of APCCdh1 activity by Cdh1/Acm1/Bmh1 ternary complex formation.Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway Spatiotemporal regulation of the anaphase-promoting complex in mitosis The SCF ubiquitin ligase: insights into a molecular machine Mouse emi1 has an essential function in mitotic progression during early embryogenesis Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes The anaphase promoting complex/cyclosome: a machine designed to destroy Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer.Cdc20: a potential novel therapeutic target for cancer treatment APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.Regulation of APC/C activators in mitosis and meiosis.APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.Control of the centriole and centrosome cycles by ubiquitination enzymes.Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division.

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Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

http://www.wikidata.org/entity/Q28343954

description

2001 nî lūn-bûn

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2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

@zh-hk

2001年論文

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2001年論文

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2001年论文

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name

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@ast

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@en

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@nl

type

label

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@ast

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@en

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@nl

prefLabel

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@ast

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@en

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

@nl

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Genes & Development

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Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

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B E Gardner

http://www.w3.org/2001/XMLSchema#string

F Margottin-Goguet

http://www.w3.org/2001/XMLSchema#string

J D Reimann

http://www.w3.org/2001/XMLSchema#string

P K Jackson

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P2860

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1

MAD2B is an inhibitor of the anaphase-promoting complex

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

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1535484

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10.1101/GAD.945701

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24

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15

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2001-12-15T00:00:00Z

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11604970

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11751633

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312853

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