The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
about
The function of APC/CCdh1 in cell cycle and beyondA MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complexHuman BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APCEvidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2betaInhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1MAD2B is an inhibitor of the anaphase-promoting complexImpairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomasZW10 links mitotic checkpoint signaling to the structural kinetochore.p31comet blocks Mad2 activation through structural mimicryThe tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complexShugoshin is a Mad1/Cdc20-like interactor of Mad2Determinants of conformational dimerization of Mad2 and its inhibition by p31cometTpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpointProbing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpointCentromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossDDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movementIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/CHec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlSil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpointMad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesisCheckpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complexIdentification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulationConformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointMammalian Cdh1/Fzr mediates its own degradationMammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsCdc20 associates with the kinase aurora2/AikThe checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in miceA new view of the spindle checkpointCheckpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cellsSpecific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activityMad2 transiently associates with an APC/p55Cdc complex during mitosisSpindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochoresRegulation of APC activity by phosphorylation and regulatory factorsStructural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model
P2860
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P2860
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The checkpoint protein MAD2 an ...... to control anaphase initiation
@ast
The checkpoint protein MAD2 an ...... to control anaphase initiation
@en
The checkpoint protein MAD2 an ...... to control anaphase initiation
@nl
type
label
The checkpoint protein MAD2 an ...... to control anaphase initiation
@ast
The checkpoint protein MAD2 an ...... to control anaphase initiation
@en
The checkpoint protein MAD2 an ...... to control anaphase initiation
@nl
prefLabel
The checkpoint protein MAD2 an ...... to control anaphase initiation
@ast
The checkpoint protein MAD2 an ...... to control anaphase initiation
@en
The checkpoint protein MAD2 an ...... to control anaphase initiation
@nl
P2093
P2860
P356
P1433
P1476
The checkpoint protein MAD2 an ...... to control anaphase initiation
@en
P2093
P2860
P304
P356
10.1101/GAD.12.12.1871
P407
P577
1998-06-15T00:00:00Z