Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
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Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathwaysIL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesisAzaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivoStable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cellsSTATs: An Old Story, Yet MesmerizingThe BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsSomatic STAT3 mutations in large granular lymphocytic leukemiaAntiproliferative Effect of Indole PhytoalexinsSTAT3 as a therapeutic target in head and neck cancerPan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cellsScoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activityOxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformationVitamin D in hematological disorders and malignancies.Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia.Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia.Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998)Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia.The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.The pathogenesis and treatment of large granular lymphocyte leukemiaHigh expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma.Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-beta1 and IL-6.Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice.Boolean network simulations for life scientists.Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets.MS-1020 is a novel small molecule that selectively inhibits JAK3 activity.Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation.Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBMPlatelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway.DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosisPreclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapyIndirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3)Celecoxib suppresses the phosphorylation of STAT3 protein and can enhance the radiosensitivity of medulloblastoma-derived cancer stem-like cells.A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells.Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis
P2860
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P2860
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@ast
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@en
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@nl
type
label
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@ast
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@en
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@nl
prefLabel
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@ast
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@en
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@nl
P2093
P2860
P356
P1476
Inhibition of STAT3 signaling ...... and decreased Mcl-1 expression
@en
P2093
H F Yang-Yen
P K Epling-Burnette
R Catlett-Falcone
R Kothapalli
P2860
P304
P356
10.1172/JCI9940
P407
P577
2001-02-01T00:00:00Z