In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta
about
Function of the C-terminus of phi29 DNA polymerase in DNA and terminal protein bindingEvidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutationsExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesDNA polymerase delta in DNA replication and genome maintenanceEukaryotic DNA polymerase ζX-ray structure of the complex of regulatory subunits of human DNA polymerase deltaAprataxin resolves adenylated RNA–DNA junctions to maintain genome integrityMismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesisDNA polymerases at the eukaryotic fork-20 years laterDNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δA Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA StrandsGermline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancersDNA replication fidelity and cancerA novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiaeDNA polymerase zeta: new insight into eukaryotic mutagenesis and mammalian embryonic developmentThe fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrationsParticipation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae.Genome instability due to ribonucleotide incorporation into DNA.Genomic instability induced by mutations in Saccharomyces cerevisiae POL1.Deposition of histone H2A.Z by the SWR-C remodeling enzyme prevents genome instabilityAlleles of the homologous recombination gene, RAD59, identify multiple responses to disrupted DNA replication in Saccharomyces cerevisiaeA novel function of DNA polymerase zeta regulated by PCNA.Cascades of genetic instability resulting from compromised break-induced replication.Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.Roles of Saccharomyces cerevisiae DNA polymerases Poleta and Polzeta in response to irradiation by simulated sunlightdNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction.Mutator alleles of yeast DNA polymerase zeta.Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cellsExtraordinary genome stability in the ciliate Paramecium tetraurelia.Human DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides.A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site.Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast.Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.
P2860
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P2860
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@ast
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@en
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@nl
type
label
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@ast
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@en
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@nl
prefLabel
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@ast
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@en
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@nl
P2093
P2860
P3181
P1433
P1476
In vivo consequences of putati ...... lpha, epsilon, delta, and zeta
@en
P2093
P V Shcherbakova
T A Kunkel
Y I Pavlov
P2860
P3181
P407
P577
2001-09-01T00:00:00Z