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A novel function of DNA polymerase zeta regulated by PCNA.

A novel function of DNA polymerase zeta regulated by PCNA.

http://www.wikidata.org/entity/Q35040027

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Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance Mechanisms underlying structural variant formation in genomic disorders PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA Eukaryotic DNA polymerase ζ Antimutator variants of DNA polymerases Structure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis † ‡A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions Distinct Structural Alterations in Proliferating Cell Nuclear Antigen Block DNA Mismatch Repair Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiae.A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage.Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.DNA polymerases at the eukaryotic fork-20 years later Genetic instability in budding and fission yeast-sources and mechanisms Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors.Ribonucleotide incorporation by yeast DNA polymerase ζ.Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae.The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis.Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis.Mutator alleles of yeast DNA polymerase zeta.A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast.PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ.Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.Proficient Replication of the Yeast Genome by a Viral DNA Polymerase The Many Roles of PCNA in Eukaryotic DNA Replication Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta.Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks.DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.

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P2860

A novel function of DNA polymerase zeta regulated by PCNA.

http://www.wikidata.org/entity/Q35040027

description

2006 nî lūn-bûn

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2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

A novel function of DNA polymerase zeta regulated by PCNA.

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A novel function of DNA polymerase zeta regulated by PCNA.

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type

label

A novel function of DNA polymerase zeta regulated by PCNA.

@ast

A novel function of DNA polymerase zeta regulated by PCNA.

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prefLabel

A novel function of DNA polymerase zeta regulated by PCNA.

@ast

A novel function of DNA polymerase zeta regulated by PCNA.

@en

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SJ.EMBOJ.7601320

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The EMBO Journal

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A novel function of DNA polymerase zeta regulated by PCNA

@en

P2093

Matthew R Northam

http://www.w3.org/2001/XMLSchema#string

Parie Garg

http://www.w3.org/2001/XMLSchema#string

Peter M J Burgers

http://www.w3.org/2001/XMLSchema#string

Polina V Shcherbakova

http://www.w3.org/2001/XMLSchema#string

P2860

Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin

A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta

MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway

Interaction with PCNA is essential for yeast DNA polymerase eta function.

Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Thymine-thymine dimer bypass by yeast DNA polymerase zeta.

Lesion bypass in yeast cells: Pol eta participates in a multi-DNA polymerase process.

New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

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4316-4325

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10.1038/SJ.EMBOJ.7601320

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18

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25

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Dmitry M Baitin

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2006-09-07T00:00:00Z

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6832045

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16957771

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1570441

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