A novel function of DNA polymerase zeta regulated by PCNA.
about
Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceMechanisms underlying structural variant formation in genomic disordersPCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNAEukaryotic DNA polymerase ζAntimutator variants of DNA polymerasesStructure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis † ‡A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactionsDistinct Structural Alterations in Proliferating Cell Nuclear Antigen Block DNA Mismatch RepairDef1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiae.A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage.Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiaeMismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.DNA polymerases at the eukaryotic fork-20 years laterGenetic instability in budding and fission yeast-sources and mechanismsSubtle alterations in PCNA-partner interactions severely impair DNA replication and repairA novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiaeEvolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors.Ribonucleotide incorporation by yeast DNA polymerase ζ.Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrationsA cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae.The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viabilityThe non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis.Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNAColon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelitydNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis.Mutator alleles of yeast DNA polymerase zeta.A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesisEmergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast.PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ.Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.Proficient Replication of the Yeast Genome by a Viral DNA PolymeraseThe Many Roles of PCNA in Eukaryotic DNA ReplicationLow-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta.Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks.DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.
P2860
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P2860
A novel function of DNA polymerase zeta regulated by PCNA.
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A novel function of DNA polymerase zeta regulated by PCNA.
@ast
A novel function of DNA polymerase zeta regulated by PCNA.
@en
type
label
A novel function of DNA polymerase zeta regulated by PCNA.
@ast
A novel function of DNA polymerase zeta regulated by PCNA.
@en
prefLabel
A novel function of DNA polymerase zeta regulated by PCNA.
@ast
A novel function of DNA polymerase zeta regulated by PCNA.
@en
P2093
P2860
P356
P1433
P1476
A novel function of DNA polymerase zeta regulated by PCNA
@en
P2093
Matthew R Northam
Parie Garg
Peter M J Burgers
Polina V Shcherbakova
P2860
P304
P356
10.1038/SJ.EMBOJ.7601320
P407
P577
2006-09-07T00:00:00Z