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Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzymeEnzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanismStructural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activityStructural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinaseStructural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.MgATP regulates allostery and fiber formation in IMPDHsCrystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulationReaction of human UMP-CMP kinase with natural and analog substratesOn dihydroorotate dehydrogenases and their inhibitors and usesThymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymesHigh content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discoveryUnique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinaseInhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunityAutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarityTwo classes of bacterial IMPDHs according to their quaternary structures and catalytic propertiesA new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.Identification of a small molecule that primes the type I interferon response to cytosolic DNA.High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening].Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidusDrug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase.Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors.Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent.Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis.Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties.Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase.
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P50
description
hulumtuese
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onderzoeker
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հետազոտող
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name
Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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type
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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H Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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Hélène Munier-Lehmann
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P1053
N-9889-2017
P106
P21
P31
P496
0000-0001-7579-8561